Communications Medicine (Feb 2023)
Development and validation of an integrative pan-solid tumor predictor of PD-1/PD-L1 blockade benefit
- Scott A. Tomlins,
- Nickolay A. Khazanov,
- Benjamin J. Bulen,
- Daniel H. Hovelson,
- Melissa J. Shreve,
- Laura E. Lamb,
- Marc R. Matrana,
- Mark E. Burkard,
- Eddy Shih-Hsin Yang,
- William Jeffery Edenfield,
- E. Claire Dees,
- Adedayo A. Onitilo,
- Michael Thompson,
- Gary L. Buchschacher,
- Alan M. Miller,
- Alexander Menter,
- Benjamin Parsons,
- Timothy Wassenaar,
- Leon C. Hwang,
- J. Marie Suga,
- Robert Siegel,
- William Irvin,
- Suresh Nair,
- Jennifer N. Slim,
- Jamal Misleh,
- Jamil Khatri,
- Gregory Masters,
- Sachdev Thomas,
- Malek Safa,
- Daniel M. Anderson,
- Kat Kwiatkowski,
- Khalis Mitchell,
- Tina Hu-Seliger,
- Stephanie Drewery,
- Andrew Fischer,
- Komal Plouffe,
- Eric Czuprenski,
- Jennifer Hipp,
- Travis Reeder,
- Hana Vakil,
- D. Bryan Johnson,
- Daniel R. Rhodes
Affiliations
- Scott A. Tomlins
- Strata Oncology
- Nickolay A. Khazanov
- Strata Oncology
- Benjamin J. Bulen
- Strata Oncology
- Daniel H. Hovelson
- Strata Oncology
- Melissa J. Shreve
- Strata Oncology
- Laura E. Lamb
- Strata Oncology
- Marc R. Matrana
- Ochsner Cancer Institute
- Mark E. Burkard
- University of Wisconsin Carbone Cancer Center
- Eddy Shih-Hsin Yang
- O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham School of Medicine
- William Jeffery Edenfield
- Prisma Health Greenville Memorial Hospital
- E. Claire Dees
- UNC Lineberger Comprehensive Cancer Center
- Adedayo A. Onitilo
- Cancer Care and Research Center, Marshfield Clinic Research Institute
- Michael Thompson
- Aurora Cancer Care, Advocate Aurora Health
- Gary L. Buchschacher
- Kaiser Permanente Southern California
- Alan M. Miller
- SCL Health-CO
- Alexander Menter
- Kaiser Permanente Colorado
- Benjamin Parsons
- Gundersen Health System
- Timothy Wassenaar
- UW Health Cancer Center at ProHealth Care
- Leon C. Hwang
- Kaiser Permanente of the Mid-Atlantic States
- J. Marie Suga
- Kaiser Permanente Northern California
- Robert Siegel
- Bon Secours St. Francis Cancer Center
- William Irvin
- Bon Secours Cancer Institute
- Suresh Nair
- Lehigh Valley Topper Cancer Institute
- Jennifer N. Slim
- MultiCare Regional Cancer Center
- Jamal Misleh
- The US Oncology Network
- Jamil Khatri
- ChristianaCare Oncology Hematology
- Gregory Masters
- Medical Oncology Hematology Consultants, Helen F Graham Cancer Center and Research Institute,
- Sachdev Thomas
- Kaiser Permanente - Northern California
- Malek Safa
- Kettering Health
- Daniel M. Anderson
- Metro-Minnesota Community Oncology Research Consortium
- Kat Kwiatkowski
- Strata Oncology
- Khalis Mitchell
- Strata Oncology
- Tina Hu-Seliger
- Strata Oncology
- Stephanie Drewery
- Strata Oncology
- Andrew Fischer
- Strata Oncology
- Komal Plouffe
- Strata Oncology
- Eric Czuprenski
- Strata Oncology
- Jennifer Hipp
- Strata Oncology
- Travis Reeder
- Strata Oncology
- Hana Vakil
- Strata Oncology
- D. Bryan Johnson
- Strata Oncology
- Daniel R. Rhodes
- Strata Oncology
- DOI
- https://doi.org/10.1038/s43856-023-00243-7
- Journal volume & issue
-
Vol. 3,
no. 1
pp. 1 – 14
Abstract
Tomlins et al. develop an Immunotherapy Response Score (IRS) to predict clinical benefit from checkpoint inhibition across solid tumors. IRS integrates TMB and gene expression, is evaluable from FFPE material, and is predictive for real-world progression-free survival and overall survival in patients receiving PD-1/PD-L1 blockade therapy.
