Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma

Abstract

Introduction: Due to the well-knownrelationship between inflammatory processes and carcinogenesis, the diagnosticand prognostic value of systemic inflammatory markers are at the focus ofresearch. This study aimed to investigate the predictive value of inflammatorycell data obtained from complete blood count in incidentally detected thyroidpapillary carcinoma.Methods: A total of 100 cases wereincluded in the study, consisting of histopathologically diagnosed multinodularhyperplasia (MNH) (N = 20), lymphocytic thyroiditis (LT) (n = 20), incidentalthyroid papillary carcinoma (ITPC) (n = 20), incidental papillary carcinoma andlymphocytic thyroiditis (ITPCLT) (n = 20), and thyroid papillary carcinoma(TPC) (n = 20). Neutrophil / lymphocyte ratio (NLR), platelet/ lymphocyte ratio(PLR), platelet/neutrophil ratio (PNR), lymphocyte/ monocyte ratio (LMR) andlymphocyte/ eosinophil ratio (LER) values were compared between the groups.Results: No significant differencewas detected between the groups concerning the mean inflammatory cell andplatelet values. However, statistical significance was observed between theITPC and ITPCLT groups regarding the mean LMR and LER values (p=0.009 andp=0.037, respectively). Higher LMR was found in the ITPC group, while higherLER was seen in the ITPCLT group.Conclusions: We suggest that besidesratios such as NLR and PLR used as systemic inflammatory markers in carcinogeneticprocesses, the evaluation of LER and LMR might be imperative as well.Therefore, these potential markers should be studied in bigger series oftumors, especially where inflammatory processes are involved in the etiology.

Keywords

• thyroid cancer
• papillary carcinoma
• lymphocytes
• eosinophils
• monocytes
• neutrophils
• tiroid kanseri
• papiler karsinom
• lenfosit
• eozinofil
• monosit
• nötrofil