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Frontiers in Cell and Developmental Biology
(Jun 2021)
Therapy Induced Genome Chaos: A Novel Mechanism of Rapid Cancer Drug Resistance
Jing Christine Ye,
Steve Horne,
Jack Z. Zhang,
Lauren Jackson,
Henry H. Heng,
Henry H. Heng
Affiliations
Jing Christine Ye
The Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States
Steve Horne
Center for Molecular Medicine and Genomics, Wayne State University School of Medicine, Detroit, MI, United States
Jack Z. Zhang
Center for Molecular Medicine and Genomics, Wayne State University School of Medicine, Detroit, MI, United States
Lauren Jackson
Center for Molecular Medicine and Genomics, Wayne State University School of Medicine, Detroit, MI, United States
Henry H. Heng
Center for Molecular Medicine and Genomics, Wayne State University School of Medicine, Detroit, MI, United States
Henry H. Heng
Department of Pathology, Wayne State University School of Medicine, Detroit, MI, United States
DOI
https://doi.org/10.3389/fcell.2021.676344
Journal volume & issue
Vol. 9
Abstract
Read online
No abstracts available.
Keywords
adaptive therapy
drug resistance
karyotype coding
non-clonal chromosome aberrations
polyploid giant cancer cells
two-phased cancer evolution
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