DNA-enabled rational design of fluorescence-Raman bimodal nanoprobes for cancer imaging and therapy

Suchetan Pal; Angana Ray; Chrysafis Andreou; Yadong Zhou; Tatini Rakshit; Marek Wlodarczyk; Masatomo Maeda; Ricardo Toledo-Crow; Naxhije Berisha; Jiang Yang; Hsiao-Ting Hsu; Anton Oseledchyk; Jagannath Mondal; Shengli Zou; Moritz F. Kircher

doi:10.1038/s41467-019-09173-2

Nature Communications (Apr 2019)

DNA-enabled rational design of fluorescence-Raman bimodal nanoprobes for cancer imaging and therapy

Suchetan Pal,
Angana Ray,
Chrysafis Andreou,
Yadong Zhou,
Tatini Rakshit,
Marek Wlodarczyk,
Masatomo Maeda,
Ricardo Toledo-Crow,
Naxhije Berisha,
Jiang Yang,
Hsiao-Ting Hsu,
Anton Oseledchyk,
Jagannath Mondal,
Shengli Zou,
Moritz F. Kircher

Affiliations

Suchetan Pal: Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center
Angana Ray: Tata Institute of Fundamental Research
Chrysafis Andreou: Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center
Yadong Zhou: Department of Chemistry, University of Central Florida
Tatini Rakshit: Department of Bioengineering, New York University
Marek Wlodarczyk: Ph.D. Program in Chemistry, The Graduate Center of the City University of New York
Masatomo Maeda: Department of Radiology, Memorial Sloan Kettering Cancer Center
Ricardo Toledo-Crow: Advanced Science Research Center, City University of New York
Naxhije Berisha: Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center
Jiang Yang: Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center
Hsiao-Ting Hsu: Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center
Anton Oseledchyk: Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center
Jagannath Mondal: Tata Institute of Fundamental Research
Shengli Zou: Department of Chemistry, University of Central Florida
Moritz F. Kircher: Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center

DOI: https://doi.org/10.1038/s41467-019-09173-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

Currently available Raman scanners are limited in speed to acquire images of clinically relevant sizes in cancer imaging. Here, the authors developed a DNA based design principle for Raman-Fluorescence bimodal nanoparticles and demonstrate real-time, high precision image-guided tumor resections and photothermal ablation of cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal