RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

Chloé Lescale; Vincent Abramowski; Marie Bedora-Faure; Valentine Murigneux; Gabriella Vera; David B. Roth; Patrick Revy; Jean-Pierre de Villartay; Ludovic Deriano

doi:10.1038/ncomms10529

Nature Communications (Feb 2016)

RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

Chloé Lescale,
Vincent Abramowski,
Marie Bedora-Faure,
Valentine Murigneux,
Gabriella Vera,
David B. Roth,
Patrick Revy,
Jean-Pierre de Villartay,
Ludovic Deriano

Affiliations

Chloé Lescale: Departments of Immunology and Genomes and Genetics, Institut Pasteur
Vincent Abramowski: Laboratory of Genome Dynamics in the Immune System, INSERM UMR1163, Université Paris Descartes Sorbonne Paris Cité, Institut Imagine
Marie Bedora-Faure: Departments of Immunology and Genomes and Genetics, Institut Pasteur
Valentine Murigneux: Departments of Immunology and Genomes and Genetics, Institut Pasteur
Gabriella Vera: Laboratory of Genome Dynamics in the Immune System, INSERM UMR1163, Université Paris Descartes Sorbonne Paris Cité, Institut Imagine
David B. Roth: Department of Pathology and Laboratory Medicine, University of Pennsylvania
Patrick Revy: Laboratory of Genome Dynamics in the Immune System, INSERM UMR1163, Université Paris Descartes Sorbonne Paris Cité, Institut Imagine
Jean-Pierre de Villartay: Laboratory of Genome Dynamics in the Immune System, INSERM UMR1163, Université Paris Descartes Sorbonne Paris Cité, Institut Imagine
Ludovic Deriano: Departments of Immunology and Genomes and Genetics, Institut Pasteur

DOI: https://doi.org/10.1038/ncomms10529
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

Antigen receptor diversity relies on careful DNA cleavage and repair. Here the authors identify a functional interplay between RAG2 and XLF during V(D)J recombination, revealing an important role for the RAG complex in repairing induced DNA double-strand breaks and maintaining genome integrity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal