Nature Communications (Jan 2019)
Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion
- Marcos Galasso,
- Jordan J. Feld,
- Yui Watanabe,
- Mauricio Pipkin,
- Cara Summers,
- Aadil Ali,
- Robert Qaqish,
- Manyin Chen,
- Rafaela V. P. Ribeiro,
- Khaled Ramadan,
- Layla Pires,
- Vanderlei S. Bagnato,
- Cristina Kurachi,
- Vera Cherepanov,
- Gray Moonen,
- Anajara Gazzalle,
- Thomas K. Waddell,
- Mingyao Liu,
- Shaf Keshavjee,
- Brian C. Wilson,
- Atul Humar,
- Marcelo Cypel
Affiliations
- Marcos Galasso
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Jordan J. Feld
- Toronto Centre for Liver Disease, University Health Network, Toronto General Hospital
- Yui Watanabe
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Mauricio Pipkin
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Cara Summers
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Aadil Ali
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Robert Qaqish
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Manyin Chen
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Rafaela V. P. Ribeiro
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Khaled Ramadan
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Layla Pires
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Vanderlei S. Bagnato
- São Carlos Institute of Physics, University of São Paulo Brazil
- Cristina Kurachi
- São Carlos Institute of Physics, University of São Paulo Brazil
- Vera Cherepanov
- Toronto Centre for Liver Disease, University Health Network, Toronto General Hospital
- Gray Moonen
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Anajara Gazzalle
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Thomas K. Waddell
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Mingyao Liu
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Shaf Keshavjee
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- Brian C. Wilson
- Princess Margaret Cancer Centre/Department of Medical Biophysics, University of Toronto
- Atul Humar
- Multi-Organ Transplant Program, University Health Network
- Marcelo Cypel
- Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network
- DOI
- https://doi.org/10.1038/s41467-018-08261-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), are not offered for transplantation due to a high risk of transmission. Here, Galasso et al. develop a method for treatment of HCV-infected human donor lungs that is safe and prevents HCV transmission in the pig model.
