Nature Communications (Apr 2023)
Homologous recombination deficiency derived from whole-genome sequencing predicts platinum response in triple-negative breast cancers
- Petra ter Brugge,
- Sarah C. Moser,
- Ivan Bièche,
- Petra Kristel,
- Sabrina Ibadioune,
- Alexandre Eeckhoutte,
- Roebi de Bruijn,
- Eline van der Burg,
- Catrin Lutz,
- Stefano Annunziato,
- Julian de Ruiter,
- Julien Masliah Planchon,
- Sophie Vacher,
- Laura Courtois,
- Rania El-Botty,
- Ahmed Dahmani,
- Elodie Montaudon,
- Ludivine Morisset,
- Laura Sourd,
- Léa Huguet,
- Heloise Derrien,
- Fariba Nemati,
- Sophie Chateau-Joubert,
- Thibaut Larcher,
- Anne Salomon,
- Didier Decaudin,
- Fabien Reyal,
- Florence Coussy,
- Tatiana Popova,
- Jelle Wesseling,
- Marc-Henri Stern,
- Jos Jonkers,
- Elisabetta Marangoni
Affiliations
- Petra ter Brugge
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Sarah C. Moser
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Ivan Bièche
- Genetics Department, Institut Curie, PSL University
- Petra Kristel
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Sabrina Ibadioune
- Genetics Department, Institut Curie, PSL University
- Alexandre Eeckhoutte
- INSERM U830, Institut Curie, PSL University
- Roebi de Bruijn
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Eline van der Burg
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Catrin Lutz
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Stefano Annunziato
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Julian de Ruiter
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Julien Masliah Planchon
- Genetics Department, Institut Curie, PSL University
- Sophie Vacher
- Genetics Department, Institut Curie, PSL University
- Laura Courtois
- Genetics Department, Institut Curie, PSL University
- Rania El-Botty
- Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University
- Ahmed Dahmani
- Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University
- Elodie Montaudon
- Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University
- Ludivine Morisset
- Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University
- Laura Sourd
- Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University
- Léa Huguet
- Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University
- Heloise Derrien
- Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University
- Fariba Nemati
- Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University
- Sophie Chateau-Joubert
- BioPôle Alfort, Ecole Nationale Vétérinaire d’Alfort
- Thibaut Larcher
- INRA, APEX-PAnTher, Oniris
- Anne Salomon
- Department of Pathology, Institut Curie, PSL University
- Didier Decaudin
- Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University
- Fabien Reyal
- Department of Surgery, Institut Curie, PSL University
- Florence Coussy
- Department of Medical Oncology, Institut Curie, PSL University
- Tatiana Popova
- INSERM U830, Institut Curie, PSL University
- Jelle Wesseling
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Marc-Henri Stern
- Genetics Department, Institut Curie, PSL University
- Jos Jonkers
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Elisabetta Marangoni
- Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University
- DOI
- https://doi.org/10.1038/s41467-023-37537-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
Homologous recombination deficiency is linked with platinum-based chemotherapy response in triple-negative breast cancer (TNBC) but methods to clinically identify these patients are lacking. Here, using patient-derived xenografts of TNBC the authors demonstrate that shallow HRD is predictive of response to platinum-based chemotherapy.
