Inverse association between the molecular spreading of IgE to grass pollen and the IgE response to Dermatophagoides pteronyssinus among children with seasonal allergic rhinitisKEY MESSAGE

Giulia Brindisi, MD, PhD; Francesca Cipriani, MD; Ekaterina Potapova; Salvatore Tripodi; Valentina Panetta; Roberto Bernardini; Carlo Caffarelli; Antonella Casani, MD; Rosa Cervone, MD; Loredana Chini; Pasquale Comberiati, MD; Giovanna De Castro; Michele Miraglia Del Giudice; Iride Dello Iacono; Andrea Di Rienzo Businco, MD; Stephanie Dramburg, MD; Marcella Gallucci, MD; Arianna Giannetti, MD; Viviana Moschese; Ifigenia Sfika, MD; Elena Varin, MD; Giampaolo Ricci; Gerald Reese, MD; Anna Maria Zicari; Paolo Maria Matricardi, PhD

World Allergy Organization Journal (Oct 2024)

Inverse association between the molecular spreading of IgE to grass pollen and the IgE response to Dermatophagoides pteronyssinus among children with seasonal allergic rhinitisKEY MESSAGE

Giulia Brindisi, MD, PhD,
Francesca Cipriani, MD,
Ekaterina Potapova,
Salvatore Tripodi,
Valentina Panetta,
Roberto Bernardini,
Carlo Caffarelli,
Antonella Casani, MD,
Rosa Cervone, MD,
Loredana Chini,
Pasquale Comberiati, MD,
Giovanna De Castro,
Michele Miraglia Del Giudice,
Iride Dello Iacono,
Andrea Di Rienzo Businco, MD,
Stephanie Dramburg, MD,
Marcella Gallucci, MD,
Arianna Giannetti, MD,
Viviana Moschese,
Ifigenia Sfika, MD,
Elena Varin, MD,
Giampaolo Ricci,
Gerald Reese, MD,
Anna Maria Zicari,
Paolo Maria Matricardi, PhD

Affiliations

Giulia Brindisi, MD, PhD: Department of Mother-Child, Urological Science, La Sapienza University, Rome, Italy; Corresponding author. Department of Mother-Child, Urological Science, La Sapienza University, Viale Regina Elena 32400161 Rome, Italy.
Francesca Cipriani, MD: Primary Care Pediatrics, AUSL Bologna, Bologna, Italy
Ekaterina Potapova: Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Augustenburger Platz 1, 13353 Berlin, Germany
Salvatore Tripodi: Pediatric Department and Pediatric Allergology Unit, Sandro Pertini Hospital, Rome, Italy
Valentina Panetta: Consultancy & Training, Biostatistics, L'altrastatistica srl, Rome, Italy
Roberto Bernardini: Pediatric Unit, San Giuseppe Hospital, Empoli, Italy
Carlo Caffarelli: Clinica Pediatrica, Department of Medicine and Surgery, University of Parma, Parma, Italy
Antonella Casani, MD: Pediatra di Libera Scelta, Benevento, Italy
Rosa Cervone, MD: Pediatric Unit, San Giuseppe Hospital, Empoli, Italy
Loredana Chini: UOSD di Immunopatologia ed Allergologia Pediatrica, Policlinico Tor Vergata, Università di Roma Tor Vergata, Rome, Italy
Pasquale Comberiati, MD: Department of Clinical and Experimental Medicine, Section of Paediatrics, University of Pisa, Pisa, Italy
Giovanna De Castro: Department of Mother-Child, Urological Science, La Sapienza University, Rome, Italy
Michele Miraglia Del Giudice: Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università della Campania Luigi Vanvitelli, Naples, Italy
Iride Dello Iacono: Pediatric Unit, Fatebenefratelli Hospital, Benevento, Italy
Andrea Di Rienzo Businco, MD: Pediatric Department and Pediatric Allergology Unit, Sandro Pertini Hospital, Rome, Italy
Stephanie Dramburg, MD: Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Augustenburger Platz 1, 13353 Berlin, Germany
Marcella Gallucci, MD: Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
Arianna Giannetti, MD: Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
Viviana Moschese: UOSD di Immunopatologia ed Allergologia Pediatrica, Policlinico Tor Vergata, Università di Roma Tor Vergata, Rome, Italy
Ifigenia Sfika, MD: Pediatric Department and Pediatric Allergology Unit, Sandro Pertini Hospital, Rome, Italy
Elena Varin, MD: Pediatric Intermediate Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Giampaolo Ricci: Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
Gerald Reese, MD: State Institute of Health, Bavarian Health and Food Safety Authority, Erlangen, Germany
Anna Maria Zicari: Department of Mother-Child, Urological Science, La Sapienza University, Rome, Italy
Paolo Maria Matricardi, PhD: Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Augustenburger Platz 1, 13353 Berlin, Germany

Journal volume & issue: Vol. 17, no. 10
p. 100975

Abstract

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Background: Seasonal allergic rhinoconjunctivitis (SAR) is a worldwide health problem, especially in Westernized countries. Previous studies of the “Panallergens in Pediatrics” (PAN-PED) cohort found that molecular spreading (ie, the progressive increase in serum specific IgE antibody levels) of the IgE response to the grass pollen, Phleum pratense, molecules is directly associated with polysensitization to pollen in general.The research question is aimed at verifying whether this association can also be detected for non-pollen allergens, specifically Dermatophagoides pteronyssinnus (D.pt), to better understand the relationship between a perennial allergen (D.pt) and a seasonal allergen (Phleum pratense).To this end, our first objective was to analyze the biobank of the PAN-PED cohort serum by measuring the IgE levels to D.pt and its major recombinant molecules (Der p1, Der p2, Der p23); subsequently we investigated their correlation towards Phleum pratense IgE response, studying also the relationship between the molecular spreading of these 2 different allergens. Methods: Among 1120 patients positive to Phleum pratense, 638 were also sensitized to D.pt. Patients underwent skin prick tests (SPT) for inhalant extracts, and their serum was tested for total IgE (tIgE), and sIgE to pollen and perennial allergens. Considering the molecular allergen detection through the component resolved diagnosis (CRD), out of 638 patients, 146 were further investigated by performing IgE tests of the 3 major D.pt. molecules: Der p1, Der p2, and Der p23. Results: We found that a broader molecular response to Phleum pratense molecules, assessed by CRD, was associated with higher tIgE levels, polysensitization to pollens, and higher IgE levels to pollens, but also to lower IgE levels to D.pt and lower degree of sensitization to rDer p1, r Der p2, and rDer p23. In a multivariate linear model, the number of Phleum pratense molecules recognized by IgE was still inversely associated with the IgE level to D.pt extract. Conclusions: The main finding of this study was the detection of an inverse association, never described in the literature, between the molecular spreading of the IgE response to Phleum pratense and the IgE response to D.pt. This led us to speculate on the etiopathogenetic hypothesis according to which, among the majority of pollen allergic patients, a strong and molecularly diversified IgE response may be limited to pollen allergens and may be preventing or contrasting the development of an equally strong and diversified IgE sensitization to D.pt molecules. The biological mechanisms underlying this phenomenon deserve to be investigated.

Published in World Allergy Organization Journal

ISSN: 1939-4551 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/world-allergy-organization-journal

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