Nature Communications (Aug 2019)
The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
- Nuria Domínguez-Iturza,
- Adrian C. Lo,
- Disha Shah,
- Marcelo Armendáriz,
- Anna Vannelli,
- Valentina Mercaldo,
- Massimo Trusel,
- Ka Wan Li,
- Denise Gastaldo,
- Ana Rita Santos,
- Zsuzsanna Callaerts-Vegh,
- Rudi D’Hooge,
- Manuel Mameli,
- Annemie Van der Linden,
- August B. Smit,
- Tilmann Achsel,
- Claudia Bagni
Affiliations
- Nuria Domínguez-Iturza
- Department of Fundamental Neurosciences, University of Lausanne
- Adrian C. Lo
- Department of Fundamental Neurosciences, University of Lausanne
- Disha Shah
- Department of Biomedical Sciences, Bio-Imaging Laboratory, University of Antwerp
- Marcelo Armendáriz
- Department of Neurosciences, Laboratory of Neuro- and Psychophysiology, KU Leuven
- Anna Vannelli
- Department of Fundamental Neurosciences, University of Lausanne
- Valentina Mercaldo
- Department of Fundamental Neurosciences, University of Lausanne
- Massimo Trusel
- Department of Fundamental Neurosciences, University of Lausanne
- Ka Wan Li
- Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam
- Denise Gastaldo
- Department of Fundamental Neurosciences, University of Lausanne
- Ana Rita Santos
- Department of Human Genetics KU Leuven, VIB Center for Brain & Disease Research
- Zsuzsanna Callaerts-Vegh
- Faculty of Psychology and Educational Sciences, KU Leuven, Laboratory of Biological Psychology
- Rudi D’Hooge
- Faculty of Psychology and Educational Sciences, KU Leuven, Laboratory of Biological Psychology
- Manuel Mameli
- Department of Fundamental Neurosciences, University of Lausanne
- Annemie Van der Linden
- Department of Biomedical Sciences, Bio-Imaging Laboratory, University of Antwerp
- August B. Smit
- Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam
- Tilmann Achsel
- Department of Fundamental Neurosciences, University of Lausanne
- Claudia Bagni
- Department of Fundamental Neurosciences, University of Lausanne
- DOI
- https://doi.org/10.1038/s41467-019-11203-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
In humans, copy-number variants of the CYFIP1 gene have been associated with autism spectrum disorders and schizophrenia. Here, the authors characterize Cyfip1-heterozygous mice, revealing that they display deficits in brain white matter structure and functional connectivity along with abnormal behaviours.
