Nature Communications (Jan 2018)
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
- Xia Jiang,
- Paul F. O’Reilly,
- Hugues Aschard,
- Yi-Hsiang Hsu,
- J. Brent Richards,
- Josée Dupuis,
- Erik Ingelsson,
- David Karasik,
- Stefan Pilz,
- Diane Berry,
- Bryan Kestenbaum,
- Jusheng Zheng,
- Jianan Luan,
- Eleni Sofianopoulou,
- Elizabeth A. Streeten,
- Demetrius Albanes,
- Pamela L. Lutsey,
- Lu Yao,
- Weihong Tang,
- Michael J. Econs,
- Henri Wallaschofski,
- Henry Völzke,
- Ang Zhou,
- Chris Power,
- Mark I. McCarthy,
- Erin D. Michos,
- Eric Boerwinkle,
- Stephanie J. Weinstein,
- Neal D. Freedman,
- Wen-Yi Huang,
- Natasja M. Van Schoor,
- Nathalie van der Velde,
- Lisette C. P. G. M. de Groot,
- Anke Enneman,
- L. Adrienne Cupples,
- Sarah L. Booth,
- Ramachandran S. Vasan,
- Ching-Ti Liu,
- Yanhua Zhou,
- Samuli Ripatti,
- Claes Ohlsson,
- Liesbeth Vandenput,
- Mattias Lorentzon,
- Johan G. Eriksson,
- M. Kyla Shea,
- Denise K. Houston,
- Stephen B. Kritchevsky,
- Yongmei Liu,
- Kurt K. Lohman,
- Luigi Ferrucci,
- Munro Peacock,
- Christian Gieger,
- Marian Beekman,
- Eline Slagboom,
- Joris Deelen,
- Diana van Heemst,
- Marcus E. Kleber,
- Winfried März,
- Ian H. de Boer,
- Alexis C. Wood,
- Jerome I. Rotter,
- Stephen S. Rich,
- Cassianne Robinson-Cohen,
- Martin den Heijer,
- Marjo-Riitta Jarvelin,
- Alana Cavadino,
- Peter K. Joshi,
- James F. Wilson,
- Caroline Hayward,
- Lars Lind,
- Karl Michaëlsson,
- Stella Trompet,
- M. Carola Zillikens,
- Andre G. Uitterlinden,
- Fernando Rivadeneira,
- Linda Broer,
- Lina Zgaga,
- Harry Campbell,
- Evropi Theodoratou,
- Susan M. Farrington,
- Maria Timofeeva,
- Malcolm G. Dunlop,
- Ana M. Valdes,
- Emmi Tikkanen,
- Terho Lehtimäki,
- Leo-Pekka Lyytikäinen,
- Mika Kähönen,
- Olli T. Raitakari,
- Vera Mikkilä,
- M. Arfan Ikram,
- Naveed Sattar,
- J. Wouter Jukema,
- Nicholas J. Wareham,
- Claudia Langenberg,
- Nita G. Forouhi,
- Thomas E. Gundersen,
- Kay-Tee Khaw,
- Adam S. Butterworth,
- John Danesh,
- Timothy Spector,
- Thomas J. Wang,
- Elina Hyppönen,
- Peter Kraft,
- Douglas P. Kiel
Affiliations
- Xia Jiang
- Program in Genetic Epidemiology and Statistical Genetics. Department of Epidemiology, Harvard T.H.Chan School of Public Health
- Paul F. O’Reilly
- Department of Social Genetic & Developmental Psychiatry, King’s College London, Institute of Psychiatry
- Hugues Aschard
- Program in Genetic Epidemiology and Statistical Genetics. Department of Epidemiology, Harvard T.H.Chan School of Public Health
- Yi-Hsiang Hsu
- Institute for Aging Research
- J. Brent Richards
- Departments of Medicine, Human Genetics, Epidemiology and Biostatistics
- Josée Dupuis
- Department of Biostatistics, Boston University School of Public Health
- Erik Ingelsson
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine Stanford
- David Karasik
- Institute for Aging Research
- Stefan Pilz
- Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz
- Diane Berry
- Population, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health
- Bryan Kestenbaum
- Kidney Research Institute, Division of Nephrology
- Jusheng Zheng
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Jianan Luan
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Eleni Sofianopoulou
- Department of Public Health & Primary Care, University of Cambridge, Strangeways Research Laboratory
- Elizabeth A. Streeten
- Genetics and Personalized Medicine Program, University of Maryland School of Medicine
- Demetrius Albanes
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Pamela L. Lutsey
- Division of Epidemiology & Community Health, School of Public Health, University of Minnesota
- Lu Yao
- Division of Epidemiology & Community Health, School of Public Health, University of Minnesota
- Weihong Tang
- Division of Epidemiology & Community Health, School of Public Health, University of Minnesota
- Michael J. Econs
- Department of Medicine, Indiana University, Endocrinology
- Henri Wallaschofski
- Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald
- Henry Völzke
- DZHK (German Centre for Cardiovascular Research), Partner Site, Greifswald
- Ang Zhou
- Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia
- Chris Power
- Population, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health
- Mark I. McCarthy
- Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford
- Erin D. Michos
- Division of Cardiology, Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine
- Eric Boerwinkle
- Human Genetics Center, University of Texas Health Science Center at Houston
- Stephanie J. Weinstein
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Neal D. Freedman
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Wen-Yi Huang
- Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Natasja M. Van Schoor
- Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center
- Nathalie van der Velde
- Erasmus MC Department of Epidemiology
- Lisette C. P. G. M. de Groot
- Department of Human Nutrition, Wageningen University
- Anke Enneman
- Erasmus MC Department of Epidemiology
- L. Adrienne Cupples
- Department of Biostatistics, Boston University School of Public Health
- Sarah L. Booth
- Vitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University
- Ramachandran S. Vasan
- Framingham Heart Study
- Ching-Ti Liu
- Department of Biostatistics, Boston University School of Public Health
- Yanhua Zhou
- Department of Biostatistics, Boston University School of Public Health
- Samuli Ripatti
- Statistical and Translational Genetics, University of Helsinki
- Claes Ohlsson
- Department of Internal Medicine and Clinical Nutrition, University of Gothenburg
- Liesbeth Vandenput
- Department of Internal Medicine and Clinical Nutrition, University of Gothenburg
- Mattias Lorentzon
- Department of Geriatric Medicine, University of Gothenburg and Sahlgrenska University Hospital
- Johan G. Eriksson
- Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki
- M. Kyla Shea
- Vitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University
- Denise K. Houston
- Sticht Center for Healthy Aging and Alzheimer’s Prevention, Wake Forest School of Medicine, Medical Center Boulevard
- Stephen B. Kritchevsky
- Sticht Center for Healthy Aging and Alzheimer’s Prevention, Wake Forest School of Medicine, Medical Center Boulevard
- Yongmei Liu
- Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine
- Kurt K. Lohman
- Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine
- Luigi Ferrucci
- Longitudinal Studies Section, Intramural Research Program of the National Institute on Aging, NIH
- Munro Peacock
- Department of Medicine, Indiana University, Endocrinology
- Christian Gieger
- German Research Center for Environmental Health, Molecular Epidemiology, AME, Ingolstädter Landstr 1
- Marian Beekman
- Molecular Epidemiology, Leiden University Medical Center, Einthovenweg 20
- Eline Slagboom
- Molecular Epidemiology, Leiden University Medical Center, Einthovenweg 20
- Joris Deelen
- Molecular Epidemiology, Leiden University Medical Center, Einthovenweg 20
- Diana van Heemst
- Gerontology and Geriatrics, Leiden University Medical Center
- Marcus E. Kleber
- Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg
- Winfried März
- Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg
- Ian H. de Boer
- Division of Nephrology and Kidney Research Institute, University of Washington
- Alexis C. Wood
- USDA/ARS Children’s Nutrition Research Center
- Jerome I. Rotter
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center
- Stephen S. Rich
- Department of Public Health Sciences, University of Virginia
- Cassianne Robinson-Cohen
- Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center
- Martin den Heijer
- Erasmus MC Department of Internal Medicine
- Marjo-Riitta Jarvelin
- Epidemiology and Biostatistics School of Public Health, Imperial College London
- Alana Cavadino
- Population, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health
- Peter K. Joshi
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- James F. Wilson
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Caroline Hayward
- MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, the University of Edinburgh, Western General Hospital
- Lars Lind
- Department of Medical Sciences, Uppsala University
- Karl Michaëlsson
- Department of Surgical Sciences, Uppsala University
- Stella Trompet
- Gerontology and Geriatrics, Leiden University Medical Center
- M. Carola Zillikens
- Erasmus MC Department of Internal Medicine
- Andre G. Uitterlinden
- Erasmus MC Department of Epidemiology
- Fernando Rivadeneira
- Erasmus MC Department of Epidemiology
- Linda Broer
- Erasmus MC Department of Internal Medicine
- Lina Zgaga
- Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, University of Dublin
- Harry Campbell
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Evropi Theodoratou
- Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
- Susan M. Farrington
- Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Maria Timofeeva
- Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Malcolm G. Dunlop
- Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Ana M. Valdes
- The Department of Twin Research & Genetic Epidemiology, King’s College London, St Thomas’ Campus
- Emmi Tikkanen
- FIMM-Institute for Molecular Medicine Finland, University of Helsinki
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories
- Mika Kähönen
- Department of Clinical Physiology, Tampere University Hospital
- Olli T. Raitakari
- Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital
- Vera Mikkilä
- Science Adviser at Academy of Finland
- M. Arfan Ikram
- Erasmus MC Department of Epidemiology
- Naveed Sattar
- BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, University Avenue
- J. Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- Nicholas J. Wareham
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Claudia Langenberg
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Nita G. Forouhi
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Thomas E. Gundersen
- Vitas AS
- Kay-Tee Khaw
- Department of Public Health & Primary Care, University of Cambridge, Strangeways Research Laboratory
- Adam S. Butterworth
- Department of Public Health & Primary Care, University of Cambridge, Strangeways Research Laboratory
- John Danesh
- Department of Public Health & Primary Care, University of Cambridge, Strangeways Research Laboratory
- Timothy Spector
- The Department of Twin Research & Genetic Epidemiology, King’s College London, St Thomas’ Campus
- Thomas J. Wang
- Division of Cardiovascular Medicine, Vanderbilt Heart and Vascular Institute
- Elina Hyppönen
- Population, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health
- Peter Kraft
- Program in Genetic Epidemiology and Statistical Genetics. Department of Epidemiology, Harvard T.H.Chan School of Public Health
- Douglas P. Kiel
- Institute for Aging Research
- DOI
- https://doi.org/10.1038/s41467-017-02662-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Vitamin D deficiency is associated with multiple human pathologic conditions. In a genome-wide association study of 79,366 individuals, Jiang et al. replicate four and identify two new genetic loci for serum levels of 25-hydroxyvitamin D and find evidence for a shared genetic basis with autoimmune diseases.
