Communications Biology (Jan 2021)
CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia
- Lennart Lenk,
- Michela Carlet,
- Fotini Vogiatzi,
- Lea Spory,
- Dorothee Winterberg,
- Antony Cousins,
- Michaela Vossen-Gajcy,
- Olta Ibruli,
- Christian Vokuhl,
- Gunnar Cario,
- Omar El Ayoubi,
- Lisa Kramer,
- Matthias Ritgen,
- Monika Brüggemann,
- Robert Häsler,
- Martin Schrappe,
- Stephan Fuhrmann,
- Christina Halsey,
- Irmela Jeremias,
- Elias Hobeika,
- Hassan Jumaa,
- Ameera Alsadeq,
- Denis M. Schewe
Affiliations
- Lennart Lenk
- Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein
- Michela Carlet
- Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Center for Environmental Health (HMGU)
- Fotini Vogiatzi
- Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein
- Lea Spory
- Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein
- Dorothee Winterberg
- Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein
- Antony Cousins
- Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Michaela Vossen-Gajcy
- Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein
- Olta Ibruli
- Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein
- Christian Vokuhl
- Department of Pathology, Section of Pediatric Pathology
- Gunnar Cario
- Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein
- Omar El Ayoubi
- Institute of Immunology, Ulm University Medical Center
- Lisa Kramer
- Institute of Immunology, Ulm University Medical Center
- Matthias Ritgen
- Department of Medicine II, University Hospital Schleswig-Holstein
- Monika Brüggemann
- Department of Medicine II, University Hospital Schleswig-Holstein
- Robert Häsler
- Institute of Clinical Molecular Biology, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein
- Martin Schrappe
- Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein
- Stephan Fuhrmann
- Department of Hematology and Oncology, HELIOS Hospital Berlin-Buch
- Christina Halsey
- Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Irmela Jeremias
- Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Center for Environmental Health (HMGU)
- Elias Hobeika
- Institute of Immunology, Ulm University Medical Center
- Hassan Jumaa
- Institute of Immunology, Ulm University Medical Center
- Ameera Alsadeq
- Institute of Immunology, Ulm University Medical Center
- Denis M. Schewe
- Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein
- DOI
- https://doi.org/10.1038/s42003-020-01591-z
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 6
Abstract
Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system (CNS). They also show that downregulation of preBCR component CD79a reduces the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
