Frontiers in Immunology (Aug 2020)

Non-invasive Assessment of Vaccine-Induced HPV Antibodies via First-Void Urine

  • Jade Pattyn,
  • Severien Van Keer,
  • Laura Téblick,
  • Pierre Van Damme,
  • Alex Vorsters

DOI
https://doi.org/10.3389/fimmu.2020.01657
Journal volume & issue
Vol. 11

Abstract

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The potential of first-void (FV) urine as a non-invasive method to monitor human papillomavirus (HPV) vaccination has been reported, mainly focusing on urine as a sample to assess HPV DNA. Besides HPV DNA, vaccine-induced HPV antibodies originating from cervicovaginal secretions were recently shown to be detectable in FV urine as well. This presents a novel opportunity for non-invasive sampling to monitor HPV antibody status in women participating in large epidemiological studies and HPV vaccine trials. The simultaneous assessment of both HPV infection and immunogenicity on a non-invasive, readily obtained sample is particularly attractive.

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