Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma: introducing a haplotype based approach

Kotnik Barbara Faganel; Jazbec Janez; Grabar Petra Bohanec; Rodriguez-Antona Cristina; Dolzan Vita

doi:10.1515/raon-2017-0040

Radiology and Oncology (Sep 2017)

Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma: introducing a haplotype based approach

Kotnik Barbara Faganel,
Jazbec Janez,
Grabar Petra Bohanec,
Rodriguez-Antona Cristina,
Dolzan Vita

Affiliations

Kotnik Barbara Faganel: Department of Oncology and Haematology, University Children’s Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia
Jazbec Janez: Department of Oncology and Haematology, University Children’s Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia
Grabar Petra Bohanec: Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Rodriguez-Antona Cristina: Hereditary Endocrine Cancer Group Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain
Dolzan Vita: Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

DOI: https://doi.org/10.1515/raon-2017-0040
Journal volume & issue: Vol. 51, no. 4
pp. 455 – 462

Abstract

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We investigated the clinical relevance of SLC 19A1 genetic variability for high dose methotrexate (HD-MTX) related toxicities in children and adolescents with acute lymphoblastic leukaemia (ALL) and non Hodgkin malignant lymphoma (NHML).

Published in Radiology and Oncology

ISSN: 1581-3207 (Online)
Publisher: Sciendo
Country of publisher: Slovenia
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://sciendo.com/journal/RAON

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Abstract

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