Clinical Implications and Prognostic Value of Leucine-Rich G Protein-Coupled Receptor 5 Expression as A Cancer Stem Cell Marker in Malignancies: A Systematic Review and Meta-Analysis

Sepideh Ghobakhloo; Mehri Khoshhali; Nasimeh Vatandoost; Sima Jafarpour; Anoosha Niazmand; Reza Nedaeinia; Rasoul Salehi

doi:10.22074/cellj.2023.2010157.1396

Cell Journal (Jan 2024)

Clinical Implications and Prognostic Value of Leucine-Rich G Protein-Coupled Receptor 5 Expression as A Cancer Stem Cell Marker in Malignancies: A Systematic Review and Meta-Analysis

Sepideh Ghobakhloo,
Mehri Khoshhali,
Nasimeh Vatandoost,
Sima Jafarpour,
Anoosha Niazmand,
Reza Nedaeinia,
Rasoul Salehi

Affiliations

Sepideh Ghobakhloo: Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Mehri Khoshhali: Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
Nasimeh Vatandoost: Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Sima Jafarpour: Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Anoosha Niazmand: Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Reza Nedaeinia: Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Diseases, Isfahan University of Medical Sciences, Isfahan, Iran
Rasoul Salehi: Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

DOI: https://doi.org/10.22074/cellj.2023.2010157.1396
Journal volume & issue: Vol. 26, no. 1
pp. 1 – 12

Abstract

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Leucine-rich G protein-coupled receptor 5 (LGR5) is a marker of cancer stem cells (CSCs) in various cancers.Based on different studies, conflicting reports exist on correlation between LGR5 expression and poor prognosis/clinicopathological parameters in cancer patients. Therefore, our purpose in conducting this study was to investigatecorrelation between LGR5 expression and outcomes of cancer patients under study through a systematic review andmeta-analysis. Relevant articles were searched and collected using EMBASE, PubMed, Science Direct, and Scopusdatabases until December 21, 2022. This study was conducted to examine correlation between LGR5 expression anddifferent clinical outcomes, such as recurrence-free survival (RFS), disease-free survival (DFS), overall survival (OS),and clinicopathological characteristics of the included cancer patients. To achieve this, hazard ratios (HRs) with 95%confidence intervals (CIs) and odds ratios (ORs) with 95% CIs were used as statistical measures. A meta-analysis wasconducted using STATA 12.0 software. Finally, 53 studies including 9523 patients met the inclusion criteria. Significantly,high-level expression of LGR5 was related to poor prognosis in terms of OS, higher tumor stage, presence of distantmetastasis, and presence of lymph node metastasis. It was discovered through subgroup analysis that several factors,including the study area, evaluation method, and type of cancer, can influence the correlation between LGR5 expressionand negative prognosis in cancer patients. According to the results of our study, LGR5 overexpression was related topoor OS in cancer patients. In addition, clinicopathological data indicated an unfavorable prognosis in cancer patientswith high LGR5 expression. In conclusion, LGR5 may serve as a potential prognostic marker for predicting survival incertain cancer types.

Published in Cell Journal

ISSN: 2228-5806 (Print); 2228-5814 (Online)
Publisher: Royan Institute (ACECR), Tehran
Country of publisher: Iran, Islamic Republic of
LCC subjects: Medicine; Science
Website: http://celljournal.org/

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