Health Science Reports (Sep 2023)

The mortality, modes of infection, diagnostic tests, and treatments of Marburg virus disease: A systematic review

  • Deekshitha Alla,
  • Sai Sri Hari Paruchuri,
  • Angad Tiwari,
  • Sai Santhosha Mrudula Alla,
  • Rakesh Thulaseedharan Pillai,
  • Sandeep Kumar Reddy Bandakadi,
  • Anju Pradeep,
  • Dhruv Jayeshkumar Shah,
  • Mert Sabıroğlu,
  • Sachi Chavda,
  • Patrick Biziyaremye

DOI
https://doi.org/10.1002/hsr2.1545
Journal volume & issue
Vol. 6, no. 9
pp. n/a – n/a

Abstract

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Abstract Background and Aims Marburg virus (MARV) has regularly affected people since 1967 causing multiple outbreaks. There are presently no authorized therapies for the fatal Marburg virus disease (MVD), which poses an imminent risk to global public health. The MVD has so far claimed the lives of numerous people, with an increased number of cases being seen throughout the African continent. Hence, a review was carried out to analyze the geographical distribution of MVD, mortality, routes of transmission, and diagnostic and treatment modalities. Methods PubMed, Scopus, Web of Science, Google Scholar, and ProMED servers were used to conduct a systematic search in compliance with the PRISMA guidelines. The results were tabulated and analyzed. Results A total of 11 studies (7 case reports and 4 case series) were included in the final analysis, and 21 cases of MVD were analyzed. The most frequent symptoms were fever (66.67%), vomiting (57.14%), headache (52.38%), diarrhea (52.38%), and pain (47.62%). The most commonly used diagnostic test was RT‐PCR (42.11%). Contact transmission (50%) and zoonotic transmission (37.5%) were the most prevalent routes of transmission. Antibiotics (61.5%) were the first line of treatment. The most common complications were hemorrhage (60%) and coagulopathies (33.3%). The mortality rate was 57.1%. Conclusion To avoid disastrous consequences, it is essential to reiterate the necessity of early diagnosis and treatment of MVD.

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