Correction of Renal Metabolic Disturbances in Acute Profuse Hemorrhage (Experimental Study)

Abstract

Objective: to comparatively evaluate the efficacy of various blood substitutes used in the correction of renal metabolic disturbances.Materials and methods. Experiments were made on 120 non-inbred male rats. Acute blood loss was simulated, by removing 50% of the volume of circulating blood from the animals for 10 min. The experiments lasted 1, 4, 7, 14, and 30 days. The kidneys were histologically and histoenzymatically studied, followed by the quantitative estimation of the rate of histochemical reactions. Morphometric measurements were statistically processed, by using Student’s t-test.Results. Acute profuse blood loss leads to the development of dystrophic changes and the inhibited activity of redox enzymes in the renal glomerular and tubular apparatuses. The multifunctional perfluorocarbon emulsion Perfluorane has a noticeable therapeutic effect in diminishing the manifestations of renal dystrophic and metabolic changes occurring in acute massive blood loss.Conclusion. Experimental results allow the author to recommend perfluorane as a more effective blood-substituting agent to diminish the damaging action of hypoxia developing in acute massive blood loss.

Keywords

• acute massive blood loss
• kidney
• perfluorane