DNA fragmentation in spermatozoa of men with infertility (literature review)

Abstract

In the literature review, data are analyzed on the violation of sperm DNA fragmentation and mechanisms of damage to DNA integrity in infertile men. The basic theories of molecular mechanisms of DNA damage and sperm chromatin abnormalities in male infertility are given. Adverse environmental conditions are generally recognized unfavorable factors, along with varicocele and pyospermia, congenital malformations and sexually transmitted infections, which affect the state of reproductive function in men. One of the mechanisms of damage to the sperm DNA integrity is high levels of reactive oxygen species. Data on the potential protective role of antioxidants in the treatment and prevention of DNA damage are presented. It was concluded that testing of sperm DNA damage and the selection of undamaged spermatozoa should be used as a part of diagnostic and therapeutic methods in couples suffering from infertility and repeated miscarriages.

Keywords

• spermatozoa
• infertility
• DNA fragmentation
• antioxidants
• chromatin