Archivio Italiano di Urologia e Andrologia (May 2023)

History of infantile BCG immunization did not predict lamina propria invasion and/or high-grade in patients with non-muscle invasive bladder cancer

  • Anastasia MacDonald,
  • Vahid Mehrnoush,
  • Asmaa Ismail,
  • Livio Di Matteo,
  • Ahmed Zakaria,
  • Waleed Shabana,
  • Ashraf Shaban,
  • Mohammed Bassuony,
  • Hazem Elmansy,
  • Walid Shahrour,
  • Owen Prowse,
  • Ahmed Kotb

DOI
https://doi.org/10.4081/aiua.2023.11380

Abstract

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Objective: To evaluate the utility of infantile BCG vaccination history in predicting stage and grade of tumours in non-muscle invasive bladder cancer (NMIBC). Materials and methods: We retrospectively analyzed data from patients from a single center who were diagnosed with new NMIBC and underwent transurethral resection of bladder tumour (TURBT) between 2017 and 2022. We assessed BCG immunization status with various demographics and comorbidities, as well as tumour recurrence, progression, stage, and grade. Results: A total of 188 patients met the inclusion criteria for our study. The mean age of patients at the time of diagnosis was significantly lower in those that had been immunized with BCG (71 ± 9) than those who had not (77 ± 10) (p < 0.0001). History of BCG immunization did not correlate with sex, history of diabetes mellitus (DM), prior history of intravesical BCG treatment, and tumour recurrence, progression, stage, and grade. Conclusions: History of infantile BCG vaccination did not correlate with the depth of invasion and/or the grade in patients with non-muscle invasive bladder cancer. Patients that received infantile BCG vaccination were significantly younger at the time of diagnosis of NMIBC.

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