Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation

Sandra Heller; Zhijian Li; Qiong Lin; Ryan Geusz; Markus Breunig; Meike Hohwieler; Xi Zhang; Gopika G. Nair; Thomas Seufferlein; Matthias Hebrok; Maike Sander; Cécile Julier; Alexander Kleger; Ivan G. Costa

doi:10.1038/s42003-021-02818-3

Communications Biology (Nov 2021)

Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation

Sandra Heller,
Zhijian Li,
Qiong Lin,
Ryan Geusz,
Markus Breunig,
Meike Hohwieler,
Xi Zhang,
Gopika G. Nair,
Thomas Seufferlein,
Matthias Hebrok,
Maike Sander,
Cécile Julier,
Alexander Kleger,
Ivan G. Costa

Affiliations

Sandra Heller: Department of Internal Medicine I, Ulm University Hospital
Zhijian Li: Institute for Computational Genomics, RWTH Aachen University Medical School
Qiong Lin: Bayer AG, Research & Development, Pharmaceuticals, Bioinformatics
Ryan Geusz: Pediatric Diabetes Research Center (PDRC) at the University of California
Markus Breunig: Department of Internal Medicine I, Ulm University Hospital
Meike Hohwieler: Department of Internal Medicine I, Ulm University Hospital
Xi Zhang: Department of Internal Medicine I, Ulm University Hospital
Gopika G. Nair: Diabetes Center at the University of California
Thomas Seufferlein: Department of Internal Medicine I, Ulm University Hospital
Matthias Hebrok: Diabetes Center at the University of California
Maike Sander: Pediatric Diabetes Research Center (PDRC) at the University of California
Cécile Julier: Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR-8104
Alexander Kleger: Department of Internal Medicine I, Ulm University Hospital
Ivan G. Costa: Institute for Computational Genomics, RWTH Aachen University Medical School

DOI: https://doi.org/10.1038/s42003-021-02818-3
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 12

Abstract

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Heller et al analyze transcriptomic and epigenetic datasets from human PSCs differentiating into pancreatic progenitors to elucidate the regulatory mechanisms behind pancreatic development. The authors report that the transcription factor ONECUT1 is expressed specifically in pancreatic development and associates with other key TFs (such as FOXA2, GATA6, PDX1) during endocrine specification.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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