Nature Communications (Mar 2019)
A threonyl-tRNA synthetase-mediated translation initiation machinery
- Seung Jae Jeong,
- Shinhye Park,
- Loi T. Nguyen,
- Jungwon Hwang,
- Eun-Young Lee,
- Hoi-Khoanh Giong,
- Jeong-Soo Lee,
- Ina Yoon,
- Ji-Hyun Lee,
- Jong Hyun Kim,
- Hoi Kyoung Kim,
- Doyeun Kim,
- Won Suk Yang,
- Seon-Young Kim,
- Chan Yong Lee,
- Kweon Yu,
- Nahum Sonenberg,
- Myung Hee Kim,
- Sunghoon Kim
Affiliations
- Seung Jae Jeong
- Medicinal Bioconvergence Research Center, Seoul National University
- Shinhye Park
- Infection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
- Loi T. Nguyen
- Infection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
- Jungwon Hwang
- Infection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
- Eun-Young Lee
- Infection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
- Hoi-Khoanh Giong
- Disease Target Structure Research Center, KRIBB
- Jeong-Soo Lee
- Disease Target Structure Research Center, KRIBB
- Ina Yoon
- Medicinal Bioconvergence Research Center, Seoul National University
- Ji-Hyun Lee
- Medicinal Bioconvergence Research Center, Seoul National University
- Jong Hyun Kim
- Medicinal Bioconvergence Research Center, Seoul National University
- Hoi Kyoung Kim
- Medicinal Bioconvergence Research Center, Seoul National University
- Doyeun Kim
- Medicinal Bioconvergence Research Center, Seoul National University
- Won Suk Yang
- Medicinal Bioconvergence Research Center, Seoul National University
- Seon-Young Kim
- KRIBB School of Bioscience, Korea University of Science and Technology
- Chan Yong Lee
- Department of Biochemistry, Chungnam National University
- Kweon Yu
- Disease Target Structure Research Center, KRIBB
- Nahum Sonenberg
- Department of Biochemistry, McGill University, Montreal
- Myung Hee Kim
- Infection and Immunity Research Laboratory, Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
- Sunghoon Kim
- Medicinal Bioconvergence Research Center, Seoul National University
- DOI
- https://doi.org/10.1038/s41467-019-09086-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
The initiation of translation is a highly regulated process that contributes to specific gene expression programs. Here the authors find that, in vertebrate, threonyl-tRNA synthetase (TRS) can act as a scaffold for the initiation machinery to stimulate the translation of a specific set of mRNAs.
