Nature Communications (Jul 2019)
Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases
- W. K. Jacky Lam,
- Peiyong Jiang,
- K. C. Allen Chan,
- Wenlei Peng,
- Huimin Shang,
- Macy M. S. Heung,
- Suk Hang Cheng,
- Haiqiang Zhang,
- O. Y. Olivia Tse,
- Radha Raghupathy,
- Brigette B. Y. Ma,
- Edwin P. Hui,
- Anthony T. C. Chan,
- John K. S. Woo,
- Rossa W. K. Chiu,
- Y. M. Dennis Lo
Affiliations
- W. K. Jacky Lam
- Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories
- Peiyong Jiang
- Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories
- K. C. Allen Chan
- Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories
- Wenlei Peng
- Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories
- Huimin Shang
- Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories
- Macy M. S. Heung
- Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories
- Suk Hang Cheng
- Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories
- Haiqiang Zhang
- Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories
- O. Y. Olivia Tse
- Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories
- Radha Raghupathy
- State Key Laboratory of Translational Oncology, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, New Territories
- Brigette B. Y. Ma
- State Key Laboratory of Translational Oncology, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, New Territories
- Edwin P. Hui
- State Key Laboratory of Translational Oncology, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, New Territories
- Anthony T. C. Chan
- State Key Laboratory of Translational Oncology, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, New Territories
- John K. S. Woo
- Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
- Rossa W. K. Chiu
- Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories
- Y. M. Dennis Lo
- Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories
- DOI
- https://doi.org/10.1038/s41467-019-11226-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Epstein-Barr virus (EBV) is associated with different malignant diseases and circulating EBV DNA is a biomarker for nasopharyngeal carcinoma (NPC). Here, the authors report that plasma EBV DNA methylation profiles show disease-associated patterns and can help to distinguish NPC and non-NPC subjects.
