SASCM guideline for daptomycin use in South Africa – 2017 update

Abstract

Daptomycin is currently registered for use in treatment of complicated skin and skin structure infections (cSSSI) and Staphylococcus aureus bacteraemia. The role of daptomycin in treatment of severe Gram-positive infections needs to be considered outside of these specific and rigid indications. Based on surveillance data, supporting literature and within the context of antimicrobial stewardship, the South African Society for Clinical Microbiology (SASCM) provides recommendations for appropriate use of daptomycin. These recommendations were formulated by members of the National Antimicrobial Committee (NAC), a sub-committee of SASCM, following consultation and review of the relevant literature.

Keywords

• antimicrobial stewardship
• antimicrobial therapy
• daptomycin
• gram-positive infections