Communications Biology (Jun 2021)
Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor
- Joseph Dowsett,
- Egil Ferkingstad,
- Line Jee Hartmann Rasmussen,
- Lise Wegner Thørner,
- Magnús K. Magnússon,
- Karen Sugden,
- Gudmar Thorleifsson,
- Mike Frigge,
- Kristoffer Sølvsten Burgdorf,
- Sisse Rye Ostrowski,
- Erik Sørensen,
- Christian Erikstrup,
- Ole Birger Pedersen,
- Thomas Folkmann Hansen,
- Karina Banasik,
- Søren Brunak,
- DBDS Genomic Consortium,
- Vinicius Tragante,
- Sigrun Helga Lund,
- Lilja Stefansdottir,
- Bjarni Gunnarson,
- Richie Poulton,
- Louise Arseneault,
- Avshalom Caspi,
- Terrie E. Moffitt,
- Daníel Gudbjartsson,
- Jesper Eugen-Olsen,
- Hreinn Stefánsson,
- Kári Stefánsson,
- Henrik Ullum
Affiliations
- Joseph Dowsett
- Department of Clinical Immunology, Copenhagen University Hospital
- Egil Ferkingstad
- deCODE genetics/Amgen Inc.
- Line Jee Hartmann Rasmussen
- Department of Psychology and Neuroscience, Duke University
- Lise Wegner Thørner
- Department of Clinical Immunology, Copenhagen University Hospital
- Magnús K. Magnússon
- deCODE genetics/Amgen Inc.
- Karen Sugden
- Department of Psychology and Neuroscience, Duke University
- Gudmar Thorleifsson
- deCODE genetics/Amgen Inc.
- Mike Frigge
- deCODE genetics/Amgen Inc.
- Kristoffer Sølvsten Burgdorf
- Department of Clinical Immunology, Copenhagen University Hospital
- Sisse Rye Ostrowski
- Department of Clinical Immunology, Copenhagen University Hospital
- Erik Sørensen
- Department of Clinical Immunology, Copenhagen University Hospital
- Christian Erikstrup
- Department of Immunology, Aarhus University Hospital
- Ole Birger Pedersen
- Department of Immunology, Naestved Hospital
- Thomas Folkmann Hansen
- Danish Headache Center, Copenhagen University Hospital, Rigshospitalet Glostrup
- Karina Banasik
- Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Søren Brunak
- Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- DBDS Genomic Consortium
- Vinicius Tragante
- deCODE genetics/Amgen Inc.
- Sigrun Helga Lund
- deCODE genetics/Amgen Inc.
- Lilja Stefansdottir
- deCODE genetics/Amgen Inc.
- Bjarni Gunnarson
- deCODE genetics/Amgen Inc.
- Richie Poulton
- Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago
- Louise Arseneault
- Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London
- Avshalom Caspi
- Department of Psychology and Neuroscience, Duke University
- Terrie E. Moffitt
- Department of Psychology and Neuroscience, Duke University
- Daníel Gudbjartsson
- deCODE genetics/Amgen Inc.
- Jesper Eugen-Olsen
- Department of Clinical Research, Copenhagen University Hospital Amager and Hvidovre
- Hreinn Stefánsson
- deCODE genetics/Amgen Inc.
- Kári Stefánsson
- deCODE genetics/Amgen Inc.
- Henrik Ullum
- Department of Clinical Immunology, Copenhagen University Hospital
- DOI
- https://doi.org/10.1038/s42003-021-02144-8
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 12
Abstract
Dowsett and colleagues used a genome-wide association approach to investigate the genetic influence on soluble urokinase-type plasminogen activator receptor presence in the plasma of humans. Their findings indicate a 60% heritability factor in British twins, and using a wide sample of Northern European genome samples they identify eleven genetic loci associated with an increase or decrease of this chronic inflammation marker.
