The Rv3799-Rv3807 Gene Cluster in  Genome Corresponds to the ‘Ancient Conserved Region’ in CMN Mycolyltransferases

Hemalatha G. Ramulu; Adindla Swathi; Lalitha Guruprasad

doi:10.1177/117693430600200015

Evolutionary Bioinformatics (Jan 2006)

The Rv3799-Rv3807 Gene Cluster in Genome Corresponds to the ‘Ancient Conserved Region’ in CMN Mycolyltransferases

Hemalatha G. Ramulu,
Adindla Swathi,
Lalitha Guruprasad

Affiliations

Hemalatha G. Ramulu: School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.
Adindla Swathi: School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.
Lalitha Guruprasad: School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.

DOI: https://doi.org/10.1177/117693430600200015
Journal volume & issue: Vol. 2

Abstract

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We have identified based on gene cluster analysis that the genes between Rv3799–Rv3807 in M. tuberculosis have orthologs in Corynebacteria, Mycobacteria and Nocardia (CMN) genomes. Therefore, this gene cluster possibly corresponds to the ‘Ancient Conserved Region’ of CMN mycolyltransferases. The evolutionary trace analysis suggests that twelve amino acid residues; Leu39, Trp51, Pro71, Trp82, Trp97, Phe100, Gly124, Ser126, Asp192, Glu230, Gly260 and Trp264 are ‘absolutely conserved’. These amino acid residues constitute the active site and conserved hydrophobic tunnel in CMN mycolyltransferases.

Published in Evolutionary Bioinformatics

ISSN: 1176-9343 (Online)
Publisher: SAGE Publishing
Country of publisher: United States
LCC subjects: Science: Biology (General): Evolution
Website: https://journals.sagepub.com/home/evb

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