Nature Communications (Feb 2017)
Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer
- Joe Ryan Delaney,
- Chandni B. Patel,
- Katelyn McCabe Willis,
- Mina Haghighiabyaneh,
- Joshua Axelrod,
- Isabelle Tancioni,
- Dan Lu,
- Jaidev Bapat,
- Shanique Young,
- Octavia Cadassou,
- Alena Bartakova,
- Parthiv Sheth,
- Carley Haft,
- Sandra Hui,
- Cheryl Saenz,
- David D. Schlaepfer,
- Olivier Harismendy,
- Dwayne G. Stupack
Affiliations
- Joe Ryan Delaney
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Chandni B. Patel
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Katelyn McCabe Willis
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Mina Haghighiabyaneh
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Joshua Axelrod
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Isabelle Tancioni
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Dan Lu
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Jaidev Bapat
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Shanique Young
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Octavia Cadassou
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Alena Bartakova
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Parthiv Sheth
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Carley Haft
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Sandra Hui
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Cheryl Saenz
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- David D. Schlaepfer
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Olivier Harismendy
- Division of Biomedical Informatics, Department of Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- Dwayne G. Stupack
- Division of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center
- DOI
- https://doi.org/10.1038/ncomms14423
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Cancers accumulate multiple single copy number alterations, but their impact is unclear. Here, the authors computationally demonstrate a disruption of genes associated with autophagy in ovarian cancer, show impact on autophagic flux, and note the efficacy of autophagy drugs in preclinical models.
