Concurrent definitive chemoradiation incorporating intensity-modulated radiotherapy followed by adjuvant chemotherapy in high risk locally advanced cervical squamous cancer: a phase II study

Gong-yi Zhang; Rong Zhang; Ping Bai; Shu-min Li; Yuan-yuan Zhang; Yi-ran Chen; Man-ni Huang; Ling-ying Wu

doi:10.1186/s12885-022-10406-9

BMC Cancer (Dec 2022)

Concurrent definitive chemoradiation incorporating intensity-modulated radiotherapy followed by adjuvant chemotherapy in high risk locally advanced cervical squamous cancer: a phase II study

Gong-yi Zhang,
Rong Zhang,
Ping Bai,
Shu-min Li,
Yuan-yuan Zhang,
Yi-ran Chen,
Man-ni Huang,
Ling-ying Wu

Affiliations

Gong-yi Zhang: Department of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Rong Zhang: Department of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Ping Bai: Department of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Shu-min Li: Department of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Yuan-yuan Zhang: Department of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Yi-ran Chen: Department of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Man-ni Huang: Department of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Ling-ying Wu: Department of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

DOI: https://doi.org/10.1186/s12885-022-10406-9
Journal volume & issue: Vol. 22, no. 1
pp. 1 – 11

Abstract

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Highlights 1. Incorporating IMRT and adjuvant chemotherapy into the treatment of locally advanced cervical cancer is highly effective. 2. IMRT is associated with a reduced loco-regional relapse. 3. Adding adjuvant TP chemotherapy could diminish tumor hematological spread. 4. Toxicity profiles were mild and manageable.

Published in BMC Cancer

ISSN: 1471-2407 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://bmccancer.biomedcentral.com

About the journal

Abstract

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