The level of some blood serum inflammatory factors in depending on the morphological features of the primary tumor of of cervical cancer

Abstract

Background. Tumors influence on various vital processes in organism leading to cachexia, immunosuppression, anemia, changes in humoral regulation etc. Inflammation is one of the well-known etiological factors of carcinogenesis, including for cervical cancer, so we suggest that some blood serum inflammatory factors in patients with cervical cancer influence are associated with the level of tumor progression.The objective of our study was to analyze the level of some hematological markers of inflammation in the blood serum of patients with cervical cancer in dependence on the histological characteristics of the primary tumors.Materials and methods. In the study we analyzed the blood serum of patients with invasive cervical cancer I–IV stage (4 patients with verrucous cancer and 26 – with cervical cancer among them 10 – of G1 stage, 6 – of G2 stage, 10 – G3 stage) using flow cytometry. We studied the value of myoglobin, calprotectin, lipocalin, matrix metalloperoxidase 2, matrix metalloperoxidase 9, osteopontin, myeloperoxidase, serum amyloid A, protein 4, insulin-like growth factor-binding protein 4, cell-cell adhesion molecule 1, vascular cell adhesion molecule, cystatin С.Results. We revealed the changes of some serum markers of inflammation in patients with G3 and verrocous cervical cancer.Conclusion. The obtained dates demonstrate that further study of blood inflammatory markers as an additional differential and prognostic criteria in patients with cervical cancer should be considered as reasonable.

Keywords

• cervical cancer
• marker of inflammation
• degree of differentiation
• verrucous cervical cancer