Aptamer-Based Biosensor Design for Simultaneous Detection of Cervical Cancer-Related MicroRNAs

Abstract

This study presents the design of an innovative aptamer-based biosensor for the detection of circulating microRNAs (miRNAs) associated with cervical cancer development. The selected panel includes circulating miRNAs known to play vital roles in cervical cancer pathogenesis, regulating processes such as cellular proliferation, migration, invasion, angiogenesis, apoptosis, inflammatory responses, and metastasis. The biosensor’s design can be optimized to ensure high sensitivity, low limits of detection, and robust performance in clinical settings. This novel biosensor design holds great promise for facilitating non-invasive detection and personalized therapeutic approaches for cervical cancer patients.

Keywords

• aptamer
• biosensor
• cervical cancer
• circulating microRNAs