Comparison of Modification of Diet in Renal Disease and Cockroft-Gault Equations in Detection of Glomerular Filtration Rate Alterations in Coronary Artery Visualized Patients

Abstract

INTRODUCTION: Contrast induced nephropathy (CIN) may arise after the use of contrast agents. Estimating of real glomerular filtration rate (GFR) is very important in order to prevent CIN. The most used GFR estimating equations are Cockroft-Gault (CG) and Modification of Diet in Renal Disease (MDRD) but their superiority to each other is unknown in contrast media used patients. METHODS: : Total of 165 patients enrolled to our study. Serum urea, creatinine and cystatin C levels of all patients were measured just before and fifth day of coronary angiography/angioplasty procedure. Alteration in serum cystatin C level was accepted as reference and GFR changes according to both equations were compared with serum cystatin C level variations. RESULTS: Decreased GFR values according to both formulas were related with an increasing in serum cystatin C levels (p¬=0.042). However, there wasn't any superiority of formulas to each other in terms of GFR alterations (r¬= -.276 and r= -.275 for CG and MDRD equations respectively). DISCUSSION AND CONCLUSION: Both CG and MDRD equations are useful to detect the GFR changes in coronary angiography performed patients and there was not superiority of them to each other. To our knowledge, this is a first study about the comparison of MDRD and CG equations in coronary artery visualized patients.

Keywords

• glomerular filtration rate
• mdrd
• cockroft-gault
• coronary angiography