<i>p</i>-Cymene Complexes of Ruthenium(II) as Antitumor Agents

María Angeles Pujante-Galián; Sergio A. Pérez; Mercedes G. Montalbán; Guzmán Carissimi; Marta G. Fuster; Gloria Víllora; Gabriel García

doi:10.3390/molecules25215063

Molecules (Oct 2020)

<i>p</i>-Cymene Complexes of Ruthenium(II) as Antitumor Agents

María Angeles Pujante-Galián,
Sergio A. Pérez,
Mercedes G. Montalbán,
Guzmán Carissimi,
Marta G. Fuster,
Gloria Víllora,
Gabriel García

Affiliations

María Angeles Pujante-Galián: Inorganic Chemistry Department, Faculty of Chemistry, Regional Campus of International Excellence “Campus Mare Nostrum”, University of Murcia, 30071 Murcia, Spain
Sergio A. Pérez: Chemical Engineering Department, Faculty of Chemistry, Regional Campus of International Excellence “Campus Mare Nostrum”, University of Murcia, 30071 Murcia, Spain
Mercedes G. Montalbán: Chemical Engineering Department, Faculty of Chemistry, Regional Campus of International Excellence “Campus Mare Nostrum”, University of Murcia, 30071 Murcia, Spain
Guzmán Carissimi: Chemical Engineering Department, Faculty of Chemistry, Regional Campus of International Excellence “Campus Mare Nostrum”, University of Murcia, 30071 Murcia, Spain
Marta G. Fuster: Chemical Engineering Department, Faculty of Chemistry, Regional Campus of International Excellence “Campus Mare Nostrum”, University of Murcia, 30071 Murcia, Spain
Gloria Víllora: Chemical Engineering Department, Faculty of Chemistry, Regional Campus of International Excellence “Campus Mare Nostrum”, University of Murcia, 30071 Murcia, Spain
Gabriel García: Inorganic Chemistry Department, Faculty of Chemistry, Regional Campus of International Excellence “Campus Mare Nostrum”, University of Murcia, 30071 Murcia, Spain

DOI: https://doi.org/10.3390/molecules25215063
Journal volume & issue: Vol. 25, no. 21
p. 5063

Abstract

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In this work, the cytotoxic behavior of six ruthenium(II) complexes of stoichiometry [(η6-p-cymene)RuCl2L] (I-VI), L = 4-cyanopyridine (I), 2-aminophenol (II), 4-aminophenol (III), pyridazine (IV), and [(η6-p-cymene)RuClL2]PF6; L = cyanopyridine (V), L = 2-aminophenol(VI) towards three cell lines was studied. Two of them, HeLa and MCF-7, are human carcinogenic cells from cervical carcinoma and human breast cancer, respectively. A comparison with healthy cells was carried out with BGM cells which are monkey epithelial cells of renal origin. The behavior of complex II exhibits selectivity towards healthy cells, which is a promising feature for use in cancer treatment since it might reduce the side effects of most current therapies.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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