Nature Communications (Apr 2021)
Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
- Hyunsoo Kim,
- Kyunghee Lee,
- Jin Man Kim,
- Mi Yeong Kim,
- Jae-Ryong Kim,
- Han-Woong Lee,
- Youn Wook Chung,
- Hong-In Shin,
- Taesoo Kim,
- Eui-Soon Park,
- Jaerang Rho,
- Seoung Hoon Lee,
- Nacksung Kim,
- Soo Young Lee,
- Yongwon Choi,
- Daewon Jeong
Affiliations
- Hyunsoo Kim
- Department of Microbiology, Laboratory of Bone Metabolism and Control, Yeungnam University College of Medicine
- Kyunghee Lee
- Department of Microbiology, Laboratory of Bone Metabolism and Control, Yeungnam University College of Medicine
- Jin Man Kim
- Department of Microbiology, Laboratory of Bone Metabolism and Control, Yeungnam University College of Medicine
- Mi Yeong Kim
- Department of Microbiology, Laboratory of Bone Metabolism and Control, Yeungnam University College of Medicine
- Jae-Ryong Kim
- Department of Biochemistry and Molecular Biology, Smart-aging Convergence Research Center, Yeungnam University College of Medicine
- Han-Woong Lee
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Youn Wook Chung
- Severance Biomedical Science Institute, Yonsei University College of Medicine
- Hong-In Shin
- IHBR, Department of Oral Pathology, School of Dentistry, Kyungpook National University
- Taesoo Kim
- Herbal Medicine Research Division, Korea Institute of Oriental Medicine
- Eui-Soon Park
- Department of Microbiology and BK21 Bio Brain Center, Chungnam National University
- Jaerang Rho
- Department of Microbiology and BK21 Bio Brain Center, Chungnam National University
- Seoung Hoon Lee
- Department of Oral Microbiology and Immunology, Wonkwang University School of Dentistry
- Nacksung Kim
- National Research Laboratory for Regulation of Bone Metabolism and Disease, Chonnam National University Medical School
- Soo Young Lee
- Division of Life and Pharmaceutical Sciences, Department of Life Science, Center for Cell Signaling & Drug Discovery Research, College of Natural Sciences, Ewha Womans University
- Yongwon Choi
- Departments of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine
- Daewon Jeong
- Department of Microbiology, Laboratory of Bone Metabolism and Control, Yeungnam University College of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-22565-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Selenoproteins containing selenium have a variety of physiological functions including redox homeostasis and thyroid hormone metabolism. Here, the authors show that RANKL-dependent repression of selenoprotein W regulates cell fusion during osteoclast differentiation and bone remodelling in mice.
