Cyclodextrines as Functional Agents for Decontamination of the Skin Contaminated by Nerve Agents

Abstract

Summary: Three decontamination solutions of β-cyclodextrines were prepared. Their abilities to decontamine rat skin contamined with nerve agent soman were tested. Decontamination efficacy of the tested cyclodextrine solutions was compared with the same decontamination means but without the cyclodextrines. The efficacy of tested decontaminants was evaluated by the assessment of the ID50 values. Two decontamination prescriptions with cyclodextrines (tetraborate buffer and tetraborate buffer with acetone) do not show significantly better decontamination efficacies in comparison with prescriptions without cyclodextrines. Only in case of aqueous solution of 2–aminoethanol the addition of β-cyclodextrine resulted in significant increase (32%) in decontamination efficacy.

Keywords

• Cyclodextrine
• Nerve agents
• Decontamination
• In vivo
• Soman
• Skin