Fate mapping reveals mixed embryonic origin and unique developmental codes of mouse forebrain septal neurons

Lorenza Magno; Zeinab Asgarian; Migle Apanaviciute; Yasmin Milner; Nora Bengoa-Vergniory; Anna Noren Rubin; Nicoletta Kessaris

doi:10.1038/s42003-022-04066-5

Communications Biology (Oct 2022)

Fate mapping reveals mixed embryonic origin and unique developmental codes of mouse forebrain septal neurons

Lorenza Magno,
Zeinab Asgarian,
Migle Apanaviciute,
Yasmin Milner,
Nora Bengoa-Vergniory,
Anna Noren Rubin,
Nicoletta Kessaris

Affiliations

Lorenza Magno: Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London
Zeinab Asgarian: Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London
Migle Apanaviciute: Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London
Yasmin Milner: Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London
Nora Bengoa-Vergniory: Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London
Anna Noren Rubin: Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London
Nicoletta Kessaris: Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London

DOI: https://doi.org/10.1038/s42003-022-04066-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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Cre transgene-based fate mapping in mice reveals that most septal neurons originate from progenitor domains in the septum and identifies Bsx as an embryonic marker and essential regulator of glutamatergic neuron development and locomotion behaviour.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal