Macromolecular and electrical coupling between inner hair cells in the rodent cochlea

Philippe Jean; Tommi Anttonen; Susann Michanski; Antonio M. G. de Diego; Anna M. Steyer; Andreas Neef; David Oestreicher; Jana Kroll; Christos Nardis; Tina Pangršič; Wiebke Möbius; Jonathan Ashmore; Carolin Wichmann; Tobias Moser

doi:10.1038/s41467-020-17003-z

Nature Communications (Jun 2020)

Macromolecular and electrical coupling between inner hair cells in the rodent cochlea

Philippe Jean,
Tommi Anttonen,
Susann Michanski,
Antonio M. G. de Diego,
Anna M. Steyer,
Andreas Neef,
David Oestreicher,
Jana Kroll,
Christos Nardis,
Tina Pangršič,
Wiebke Möbius,
Jonathan Ashmore,
Carolin Wichmann,
Tobias Moser

Affiliations

Philippe Jean: Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen
Tommi Anttonen: Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen
Susann Michanski: Collaborative Research Center 889, University of Göttingen
Antonio M. G. de Diego: UCL Ear Institute and Department of Neuroscience, Physiology and Pharmacology, University College London
Anna M. Steyer: Electron Microscopy Core Unit, Department of Neurogenetics, Max Planck Institute of Experimental Medicine
Andreas Neef: Neurophysics laboratory, Campus Institute for Dynamics of Biological Networks, University of Göttingen
David Oestreicher: Experimental Otology Group, Institute for Auditory Neuroscience, InnerEarLab, and Department of Otolaryngology, University Medical Center Göttingen
Jana Kroll: Collaborative Research Center 889, University of Göttingen
Christos Nardis: Electron Microscopy Core Unit, Department of Neurogenetics, Max Planck Institute of Experimental Medicine
Tina Pangršič: Collaborative Research Center 889, University of Göttingen
Wiebke Möbius: Electron Microscopy Core Unit, Department of Neurogenetics, Max Planck Institute of Experimental Medicine
Jonathan Ashmore: UCL Ear Institute and Department of Neuroscience, Physiology and Pharmacology, University College London
Carolin Wichmann: Collaborative Research Center 889, University of Göttingen
Tobias Moser: Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen

DOI: https://doi.org/10.1038/s41467-020-17003-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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The inner hair cells (IHCs) within the cochlea convey sound information and have been thought to be electrically and metabolically independent from each other. Here authors report that a subset of IHCs are electrochemically coupled in ‘mini-syncytia’.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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