Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling

Huang-Ming Cao; Xiao-Ping Ye; Jun-Hua Ma; He Jiang; Sheng-Xian Li; Rong-Ying Li; Xue-Song Li; Cui-Cui Guo; Zhi-Quan Wang; Ming Zhan; Chun-Lin Zuo; Chun-Ming Pan; Shuang-Xia Zhao; Cui-Xia Zheng; Huai-Dong Song

doi:10.1016/j.ebiom.2015.09.044

EBioMedicine (Nov 2015)

Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling

Huang-Ming Cao,
Xiao-Ping Ye,
Jun-Hua Ma,
He Jiang,
Sheng-Xian Li,
Rong-Ying Li,
Xue-Song Li,
Cui-Cui Guo,
Zhi-Quan Wang,
Ming Zhan,
Chun-Lin Zuo,
Chun-Ming Pan,
Shuang-Xia Zhao,
Cui-Xia Zheng,
Huai-Dong Song

Affiliations

Huang-Ming Cao: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Xiao-Ping Ye: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Jun-Hua Ma: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
He Jiang: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Sheng-Xian Li: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Rong-Ying Li: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Xue-Song Li: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Cui-Cui Guo: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Zhi-Quan Wang: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Ming Zhan: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Chun-Lin Zuo: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Chun-Ming Pan: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Shuang-Xia Zhao: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Cui-Xia Zheng: Medical Center of Clinical Research, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
Huai-Dong Song: State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

DOI: https://doi.org/10.1016/j.ebiom.2015.09.044
Journal volume & issue: Vol. 2, no. 11
pp. 1718 – 1724

Abstract

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Adipokines such as leptin play important roles in the regulation of energy metabolism, particularly in the control of appetite. Here, we describe a hormone, mimecan, which is abundantly expressed in adipose tissue. Mimecan was observed to inhibit food intake and reduce body weight in mice. Intraperitoneal injection of a mimecan-maltose binding protein (-MBP) complex inhibited food intake in C57BL/6J mice, which was attenuated by pretreatment with polyclonal antibody against mimecan. Notably, mimecan-MBP also induced anorexia in Ay/a and db/db mice. Furthermore, the expression of interleukin (IL)-1β and IL-6 was up-regulated in the hypothalamus by mimecan-MBP, as well as in N9 microglia cells by recombinant mouse mimecan. Taken together, the results suggest that mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin signaling by inducing IL-1β and IL-6 expression in the hypothalamus.

Published in EBioMedicine

ISSN: 2352-3964 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General)
Website: http://www.journals.elsevier.com/ebiomedicine/

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