S-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen

Dan Gu; Yibei Zhang; Qiyao Wang; Xiaohui Zhou

doi:10.1038/s41467-020-19506-1

Nature Communications (Nov 2020)

S-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen

Dan Gu,
Yibei Zhang,
Qiyao Wang,
Xiaohui Zhou

Affiliations

Dan Gu: Department of Pathobiology and Veterinary Science, University of Connecticut
Yibei Zhang: Department of Pathobiology and Veterinary Science, University of Connecticut
Qiyao Wang: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Xiaohui Zhou: Department of Pathobiology and Veterinary Science, University of Connecticut

DOI: https://doi.org/10.1038/s41467-020-19506-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 19

Abstract

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Vibrio parahaemolyticus causes seafood-borne diarrheal diseases. Here, the authors show that the pathogen uses a histidine kinase to sense host-derived nitrite and downregulate a proinflammatory type 3 secretion system, thus enhancing intestinal colonization and virulence.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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