Nature Communications (Nov 2017)
Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses
- Houze Zhu,
- Huanhuan Yan,
- Na Tang,
- Xinyan Li,
- Pei Pang,
- Hao Li,
- Wenting Chen,
- Yu Guo,
- Shu Shu,
- You Cai,
- Lei Pei,
- Dan Liu,
- Min-Hua Luo,
- Hengye Man,
- Qing Tian,
- Yangling Mu,
- Ling-Qiang Zhu,
- Youming Lu
Affiliations
- Houze Zhu
- Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
- Huanhuan Yan
- Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
- Na Tang
- Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
- Xinyan Li
- Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
- Pei Pang
- Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
- Hao Li
- Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
- Wenting Chen
- Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
- Yu Guo
- Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
- Shu Shu
- Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
- You Cai
- Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
- Lei Pei
- The Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology
- Dan Liu
- The Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology
- Min-Hua Luo
- State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Wuhan Institute of Virology, Chinese Academy of Sciences
- Hengye Man
- The Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology
- Qing Tian
- The Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology
- Yangling Mu
- Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
- Ling-Qiang Zhu
- Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
- Youming Lu
- Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-017-01943-0
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Cholinergic neurons in the diagonal band of Broca degenerate early in Alzheimer’s disease. Here the authors show that in healthy mice, these cholinergic inputs innervate newborn neurons in the hippocampus, and that loss of this innervation in an Alzheimer’s disease model leads to impairments in spatial memory.
