Estimated methods of predicting risk of analgetic interstitial renal disease

Abstract

Aim. Screening of renal pathology and investigation of its dependence on intake of metamisol, the risk of nephritis associated with metamisol. Material and methods. The study included 1446 inpatients (mean age 49.63 ± 0.43 years, 690 males - 48%, 756 females - 52%). Analysis of the urine, tests for urea, blood creatinine, estimation of glomerular filtration rate were made. Metamisol doses and duration of analgetic treatment were controlled in 658 patients. Statistical processing was made with Statistica 6.0 soft. Results. Of 1446 examinees, 346 (23.9%) patients took analgetics. Out of 98 patients treated with metamisol, 34(34.7%) had pathology of urinary sediment, 18 (18.4%) had suppression of renal function (RF) while in patients untreated with analgetics this percentage was 7.4 and 16.1%, respectively, p < 0.05. In intake of metamisol from 0.5 to 5.0 kg and more changes in urine analysis parameters and regress of RF were more prominent than in intake up to 0.5 kg (p

Keywords

• metamisol
• analgetic nephropathy
• tubulointerstitial nephriti