A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin

Abstract

In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2–DDX5 interaction is impaired in cells expressing the BRCA2T207A missense variant found in breast cancer patients.

Keywords

• brca2
• breast cancer
• ddx5
• dna-rna hybrid
• double-strand break
• homologous recombination
• dsb repair