Nature Communications (Dec 2018)
Loss of Phd2 cooperates with BRAF V600E to drive melanomagenesis
- Shujing Liu,
- Gao Zhang,
- Jianping Guo,
- Xiang Chen,
- Jingce Lei,
- Kan Ze,
- Liyun Dong,
- Xiangpeng Dai,
- Yang Gao,
- Daisheng Song,
- Brett L. Ecker,
- Ruifeng Yang,
- Caitlin Feltcher,
- Kai Peng,
- Cheng Feng,
- Hui Chen,
- Rebecca X. Lee,
- Heddy Kerestes,
- Jingwen Niu,
- Suresh Kumar,
- Weiting Xu,
- Jie Zhang,
- Zhi Wei,
- James S. Martin,
- Xiaoming Liu,
- Gordon Mills,
- Yiling Lu,
- Wei Guo,
- Lunquan Sun,
- Lin Zhang,
- Ashani Weeraratna,
- Meenhard Herlyn,
- Wenyi Wei,
- Frank S. Lee,
- Xiaowei Xu
Affiliations
- Shujing Liu
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Gao Zhang
- The Wistar Institute
- Jianping Guo
- Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Xiang Chen
- Xiangya Hospital, Central South University
- Jingce Lei
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Kan Ze
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Liyun Dong
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Xiangpeng Dai
- Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Yang Gao
- Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Daisheng Song
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Brett L. Ecker
- The Wistar Institute
- Ruifeng Yang
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Caitlin Feltcher
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Kai Peng
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Cheng Feng
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Hui Chen
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Rebecca X. Lee
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Heddy Kerestes
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Jingwen Niu
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Suresh Kumar
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Weiting Xu
- Department of Computer Science, New Jersey Institute of Technology
- Jie Zhang
- Department of Computer Science, New Jersey Institute of Technology
- Zhi Wei
- Department of Computer Science, New Jersey Institute of Technology
- James S. Martin
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Xiaoming Liu
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Gordon Mills
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Yiling Lu
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Wei Guo
- Department of Biology, School of Arts and Sciences, University of Pennsylvania
- Lunquan Sun
- Xiangya Hospital, Central South University
- Lin Zhang
- Center for Research on Reproduction & Women’s Health, University of Pennsylvania
- Ashani Weeraratna
- The Wistar Institute
- Meenhard Herlyn
- The Wistar Institute
- Wenyi Wei
- Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Frank S. Lee
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Xiaowei Xu
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- DOI
- https://doi.org/10.1038/s41467-018-07126-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Prolyl hydroxylase domain protein 2 (PHD2) regulates cellular response to hypoxia. Here the authors show that PHD2 is downregulated in melanoma and that PHD2 depletion, in a mouse model, promotes the progression of benign melanocytic lesions into melanoma, via activation of the Akt/mTOR signaling cascade.
