The effects of antioxidant dietary supplements on oxidative stress and its implications in Metabolic Syndrome: a review

Abstract

The aim was to perform a review in order to elucidate the actions and efficacy of different antioxidant supplements used on Metabolic Syndrome. The articles were searched during October of 2015 to December of 2018, using the databases PubMed and Web of Knowledge. The keywords used were: “Metabolic Syndrome” AND “dietary supplements” OR “antioxidant”. The included articles were published from 2010 and in English. It was applied for articles selection inclusion and exclusion criteria. The articles that fulfilled criteria were analyzed through a full-text reading. Search results in 368 articles (PubMed: 198; Web of Knowledge: 170). After eliminating duplicated data and applying criteria, 16 articles were included to the review. The antioxidant supplements used on the studies included eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), nigella sativa (NS) and garlic, superoxide dismutase (SOD), cholecalciferol, Coenzyme Q10 (CoQ10), quercetin dehydrate, glycine, α-lipoic acid (ALA), glutathione precursor (F1), taurine, phenolic acids, red yeast rice-olive extract, curcumin, goji berry and arginine. Findings demonstrate a decrease in oxidative stress by increasing antioxidant enzyme activity, G6DH, Nrf2 with a consequently positive effect on insulin sensitivity, glucose tolerance, improvement in lipid profile, decrease on inflammatory and endothelium dysfunction markers with antioxidant supplements. Therefore, we could conclude that supplementation with antioxidant potential is able to ameliorate parameters of Metabolic Syndrome.

Keywords

• Metabolic Syndrome X
• Dietary supplements
• Antioxidant
• Oxidative stress