Communications Biology (Aug 2022)
Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma
- Lauren Broestl,
- Nicole M. Warrington,
- Lucia Grandison,
- Tamara Abou-Antoun,
- Olivia Tung,
- Saraswati Shenoy,
- Miranda M. Tallman,
- Gina Rhee,
- Wei Yang,
- Jasmin Sponagel,
- Lihua Yang,
- Najla Kfoury-Beaumont,
- Cameron M. Hill,
- Sulaiman A. Qanni,
- Diane D. Mao,
- Albert H. Kim,
- Sheila A. Stewart,
- Monica Venere,
- Jingqin Luo,
- Joshua B. Rubin
Affiliations
- Lauren Broestl
- Department of Pediatrics, Washington University School of Medicine
- Nicole M. Warrington
- Department of Pediatrics, Washington University School of Medicine
- Lucia Grandison
- Department of Pediatrics, Washington University School of Medicine
- Tamara Abou-Antoun
- Department of Pediatrics, Washington University School of Medicine
- Olivia Tung
- Department of Pediatrics, Washington University School of Medicine
- Saraswati Shenoy
- Brown School, Washington University in St. Louis
- Miranda M. Tallman
- Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University Wexner School of Medicine
- Gina Rhee
- Department of Pediatrics, Washington University School of Medicine
- Wei Yang
- Department of Genetics, Washington University School of Medicine
- Jasmin Sponagel
- Department of Pediatrics, Washington University School of Medicine
- Lihua Yang
- Department of Pediatrics, Washington University School of Medicine
- Najla Kfoury-Beaumont
- Department of Pediatrics, Washington University School of Medicine
- Cameron M. Hill
- Department of Pediatrics, Washington University School of Medicine
- Sulaiman A. Qanni
- Department of Pediatrics, Washington University School of Medicine
- Diane D. Mao
- Department of Neurosurgery, Washington University School of Medicine
- Albert H. Kim
- Department of Neurosurgery, Washington University School of Medicine
- Sheila A. Stewart
- Siteman Cancer Center, Washington University School of Medicine
- Monica Venere
- Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University Wexner School of Medicine
- Jingqin Luo
- Department of Surgery, Washington University School of Medicine
- Joshua B. Rubin
- Department of Pediatrics, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/s42003-022-03743-9
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 18
Abstract
In human and murine GBM cells, and wildtype murine astrocytes, radiation induces senescence. Overall, female cells are more sensitive to radiation and to p21-induced senescence. This may contribute to the female survival advantage in GBM.
