HYPOGLYCAEMIC EVALUATION OF ETHANOLIC EXTRACT OF RHIZOME OF COSTUS SPECIOSUS IN ALLOXAN INDUCED DIABETIC RATS

Abstract

The present study was carried out to evaluate the hypoglycaemic effect of ethanolic extract of Costus speciosus. The extract was given at three different doses 250 mg/kg, 500 mg/kg and 750 mg/kg, and it was found that all the three doses significantly reduced (P<0.05) the blood glucose level. The reference drug (glibenclamide) and extract were administered orally in distilled water as vehicle for 45 days. All the treatment groups except the normal control was made diabetic by intraperitoneal injection of alloxan monohydrate at the dose rate of 130 mg/kg body weight for two consecutive days. The study confirmed that plant extract possessed the hypoglycaemic activity

Keywords

• costus speciosus
• hypoglycemic and alloxan