Severe Hypoglycemia Caused by a Giant Borderline Phyllodes Tumor of the Breast: A Case Report and Literature Review

Yaoxia Liu; Yaoxia Liu; Min Zhang; Min Zhang; Xudan Yang; Xudan Yang; Min Zhang; Min Zhang; Zhen Fan; Zhen Fan; Yi Li; Yi Li; Tao Wang; Tao Wang; Tao Wang; Ping Chen; Ping Chen

doi:10.3389/fendo.2022.871998

Frontiers in Endocrinology (May 2022)

Severe Hypoglycemia Caused by a Giant Borderline Phyllodes Tumor of the Breast: A Case Report and Literature Review

Yaoxia Liu,
Yaoxia Liu,
Min Zhang,
Min Zhang,
Xudan Yang,
Xudan Yang,
Min Zhang,
Min Zhang,
Zhen Fan,
Zhen Fan,
Yi Li,
Yi Li,
Tao Wang,
Tao Wang,
Tao Wang,
Ping Chen,
Ping Chen

Affiliations

Yaoxia Liu: Department of Geriatrics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Yaoxia Liu: Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China
Min Zhang: Department of Geriatrics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Min Zhang: Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China
Xudan Yang: Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China
Xudan Yang: Department of Pathology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Min Zhang: Department of Geriatrics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Min Zhang: Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China
Zhen Fan: Department of Geriatrics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Zhen Fan: Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China
Yi Li: Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China
Yi Li: Mastology Department, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Tao Wang: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Tao Wang: Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China
Tao Wang: The Cardiac Development and Early Intervention Unit, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, China
Ping Chen: Department of Geriatrics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Ping Chen: Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China

DOI: https://doi.org/10.3389/fendo.2022.871998
Journal volume & issue: Vol. 13

Abstract

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A case of hypoglycemic coma caused by a giant borderline phyllodes tumor of the breast has been described. The patient, a 63-year-old woman, was admitted with recurrent unconsciousness. She had a giant breast tumor with decreased blood glucose, insulin, and C-peptide. The patient’s hypoglycemia resolved rapidly after resection of the breast tumor. Pathological examination indicated a borderline phyllodes tumor of the breast, and immunohistochemistry suggested high expression of insulin-like growth factor-2 (IGF-2) in the tumor tissue. A literature review is also included to summarize the clinical characteristics of such patients and to serve as a unique resource for clinical diagnosis and treatment of similar cases.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

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