Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma

Mark Manzano; Ajinkya Patil; Alexander Waldrop; Sandeep S. Dave; Amir Behdad; Eva Gottwein

doi:10.1038/s41467-018-05506-9

Nature Communications (Aug 2018)

Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma

Mark Manzano,
Ajinkya Patil,
Alexander Waldrop,
Sandeep S. Dave,
Amir Behdad,
Eva Gottwein

Affiliations

Mark Manzano: Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University
Ajinkya Patil: Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University
Alexander Waldrop: Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University
Sandeep S. Dave: Duke Cancer Institute and Center for Genomic and Computational Biology, Duke University
Amir Behdad: Department of Pathology, Feinberg School of Medicine, Northwestern University
Eva Gottwein: Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University

DOI: https://doi.org/10.1038/s41467-018-05506-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Our understanding of the genetics and treatment options for primary effusion lymphoma (PEL) is lacking. Here the authors performed in vitro CRISPR/Cas9 knock-out screens to identify 210 PEL-specific oncogenic genes and report strategies for therapeutic intervention.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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