Nature Communications (Aug 2021)
OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human
- Xin Huang,
- Kyoung-mi Park,
- Paul Gontarz,
- Bo Zhang,
- Joshua Pan,
- Zachary McKenzie,
- Laura A. Fischer,
- Chen Dong,
- Sabine Dietmann,
- Xiaoyun Xing,
- Pavel V. Shliaha,
- Jihong Yang,
- Dan Li,
- Junjun Ding,
- Tenzin Lungjangwa,
- Maya Mitalipova,
- Shafqat A. Khan,
- Sumeth Imsoonthornruksa,
- Nick Jensen,
- Ting Wang,
- Cigall Kadoch,
- Rudolf Jaenisch,
- Jianlong Wang,
- Thorold W. Theunissen
Affiliations
- Xin Huang
- Department of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Columbia University Irving Medical Center
- Kyoung-mi Park
- Department of Developmental Biology, Washington University School of Medicine
- Paul Gontarz
- Department of Developmental Biology, Washington University School of Medicine
- Bo Zhang
- Department of Developmental Biology, Washington University School of Medicine
- Joshua Pan
- Department of Pediatric Oncology, Dana-Farber Cancer Institute
- Zachary McKenzie
- Department of Pediatric Oncology, Dana-Farber Cancer Institute
- Laura A. Fischer
- Department of Developmental Biology, Washington University School of Medicine
- Chen Dong
- Department of Developmental Biology, Washington University School of Medicine
- Sabine Dietmann
- Department of Developmental Biology, Washington University School of Medicine
- Xiaoyun Xing
- Center of Regenerative Medicine, Washington University School of Medicine
- Pavel V. Shliaha
- Memorial Sloan Kettering Cancer Center
- Jihong Yang
- Department of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Columbia University Irving Medical Center
- Dan Li
- Department of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Columbia University Irving Medical Center
- Junjun Ding
- Department of Cell, Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai
- Tenzin Lungjangwa
- Whitehead Institute for Biomedical Research
- Maya Mitalipova
- Whitehead Institute for Biomedical Research
- Shafqat A. Khan
- Department of Developmental Biology, Washington University School of Medicine
- Sumeth Imsoonthornruksa
- Whitehead Institute for Biomedical Research
- Nick Jensen
- Department of Developmental Biology, Washington University School of Medicine
- Ting Wang
- Center of Regenerative Medicine, Washington University School of Medicine
- Cigall Kadoch
- Department of Pediatric Oncology, Dana-Farber Cancer Institute
- Rudolf Jaenisch
- Whitehead Institute for Biomedical Research
- Jianlong Wang
- Department of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Columbia University Irving Medical Center
- Thorold W. Theunissen
- Department of Developmental Biology, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-25107-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Although the interactors of pluripotency factors have been identified in mouse embryonic stem cells (ESCs), their interactors in human ESCs remain unexplored. Here the authors map OCT4 protein interactions in naïve and primed human ESCs to find specific interactions with BAF subunits that promote an open chromatin architecture at blastocyst-associated genes and ectodermal genes, respectively.
