B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis

Yuwen Li; Xiaodan Ma; Zhiming Chen; Haiyan Wu; Pengran Wang; Wenyu Wu; Nuo Cheng; Longhui Zeng; Hao Zhang; Xun Cai; Sai-Juan Chen; Zhu Chen; Guoyu Meng

doi:10.1038/s41467-019-11746-0

Nature Communications (Aug 2019)

B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis

Yuwen Li,
Xiaodan Ma,
Zhiming Chen,
Haiyan Wu,
Pengran Wang,
Wenyu Wu,
Nuo Cheng,
Longhui Zeng,
Hao Zhang,
Xun Cai,
Sai-Juan Chen,
Zhu Chen,
Guoyu Meng

Affiliations

Yuwen Li: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Xiaodan Ma: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Zhiming Chen: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Haiyan Wu: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Pengran Wang: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Wenyu Wu: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Nuo Cheng: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Longhui Zeng: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Hao Zhang: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Xun Cai: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Sai-Juan Chen: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Zhu Chen: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Guoyu Meng: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-11746-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

Promyelocytic leukemia protein (PML) is the scaffolding protein that organizes PML nuclear bodies. Here the authors determine the crystal structure of a PML B1-box multimer and characterise the oligomerisation behaviour of the PML RBCC construct and show that disrupting B1-B1 interactions precludes promyelocytic leukemia leukemogenesis in transgenic mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal