Nature Communications (Dec 2020)
Neutralizing the pathological effects of extracellular histones with small polyanions
- Connor H. O’ Meara,
- Lucy A. Coupland,
- Farzaneh Kordbacheh,
- Benjamin J. C. Quah,
- Chih-Wei Chang,
- David A. Simon Davis,
- Anna Bezos,
- Anna M. Browne,
- Craig Freeman,
- Dillon J. Hammill,
- Pradeep Chopra,
- Gergely Pipa,
- Paul D. Madge,
- Esther Gallant,
- Courtney Segovis,
- Angela F. Dulhunty,
- Leonard F. Arnolda,
- Imogen Mitchell,
- Levon M. Khachigian,
- Ross W. Stephens,
- Mark von Itzstein,
- Christopher R. Parish
Affiliations
- Connor H. O’ Meara
- ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University
- Lucy A. Coupland
- ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University
- Farzaneh Kordbacheh
- ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University
- Benjamin J. C. Quah
- ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University
- Chih-Wei Chang
- Institute for Glycomics, Griffith University
- David A. Simon Davis
- ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University
- Anna Bezos
- ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University
- Anna M. Browne
- ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University
- Craig Freeman
- ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University
- Dillon J. Hammill
- ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University
- Pradeep Chopra
- Institute for Glycomics, Griffith University
- Gergely Pipa
- Institute for Glycomics, Griffith University
- Paul D. Madge
- Institute for Glycomics, Griffith University
- Esther Gallant
- Eccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University
- Courtney Segovis
- Eccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University
- Angela F. Dulhunty
- Eccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University
- Leonard F. Arnolda
- Illawarra Health and Medical Research Institute
- Imogen Mitchell
- Intensive Care Unit, The Canberra Hospital
- Levon M. Khachigian
- Vascular Biology and Translational Research, School of Medical Sciences, University of New South Wales
- Ross W. Stephens
- Department of Applied Mathematics, Research School of Physics and Engineering, The Australian National University
- Mark von Itzstein
- Institute for Glycomics, Griffith University
- Christopher R. Parish
- ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University
- DOI
- https://doi.org/10.1038/s41467-020-20231-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Histones, proteins that bind DNA, are toxic for pathogens outside cells but can also cause multi-organ damage as seen in sepsis. Here the authors develop small negatively charged molecules that can be used as histone antidotes, and show that they improve the phenotype in mouse models with histone-related pathologies.
