Overexpression of blaSHV-12 caused by tandem amplification contributed to ceftazidime/avibactam resistance in hypervirulent and carbapenem-resistant Klebsiella pneumoniae

Chao Liu; Juan Yi; Ping Yang; Chunjing Du; Fan Jiang; Ming Lu; Pengcheng Du; Ning Shen

doi:10.1080/22221751.2024.2426481

Emerging Microbes and Infections (Dec 2024)

Overexpression of blaSHV-12 caused by tandem amplification contributed to ceftazidime/avibactam resistance in hypervirulent and carbapenem-resistant Klebsiella pneumoniae

Chao Liu,
Juan Yi,
Ping Yang,
Chunjing Du,
Fan Jiang,
Ming Lu,
Pengcheng Du,
Ning Shen

Affiliations

Chao Liu: Department of Infectious Disease, Peking University Third Hospital, Beijing, People’s Republic of China
Juan Yi: Institute of Medical Technology, Peking University Health Science Center, Beijing, People’s Republic of China
Ping Yang: Institute of Medical Technology, Peking University Health Science Center, Beijing, People’s Republic of China
Chunjing Du: Center of Infectious Disease, Peking University Third Hospital, Beijing, People’s Republic of China
Fan Jiang: Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing, People’s Republic of China
Ming Lu: Department of Infectious Disease, Peking University Third Hospital, Beijing, People’s Republic of China
Pengcheng Du: Qitan Technology Ltd., Chengdu, People’s Republic of China
Ning Shen: Department of Infectious Disease, Peking University Third Hospital, Beijing, People’s Republic of China

DOI: https://doi.org/10.1080/22221751.2024.2426481
Journal volume & issue: Vol. 13, no. 1

Abstract

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We identified a novel ceftazidime/avibactam (CAZ/AVI) resistance mechanism in endemic sequence type 11 hypervirulent and carbapenem-resistant Klebsiella pneumoniae isolated from a patient who had not been exposed CAZ/AVI. Overexpression of blaSHV-12 caused by tandem gene amplification contributed to CAZ/AVI resistance instead of the carriage of blaKPC-2. Enhanced genomic surveillance is essential to identify emerging variants.

Published in Emerging Microbes and Infections

ISSN: 2222-1751 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Science: Microbiology
Website: https://www.tandfonline.com/journals/temi

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