Olfactory marker protein regulates prolactin secretion and production by modulating Ca2+ and TRH signaling in lactotrophs

Abstract

Reproductive health: Prolactin hormone regulation revealed Uncovering the regulatory mechanism behind production of the prolactin hormone may help tackle reproductive health problems. As well as triggering milk production in female mammals, prolactin is critical for healthy reproduction in both sexes. An excess of prolactin secreted by cells called lactotrophs in the pituitary gland can cause infertility. While scientists know which hormones stimulate prolactin release, how prolactin levels are regulated is unclear. Eun Jig Lee and Cheol Ryong Ku at Yonsei University in Seoul, Korea, and co-workers demonstrated that the olfactory marker protein (OMP) plays a central role in regulating prolactin production. They found that OMP specifically and highly expressed in lactotrophs. Eliminating OMP expression in mice left a key signalling pathway and calcium ion levels upregulated, resulting in increased prolactin and reduced fertility.